Adaptor Molecule TRIF in Teleost

Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v1i2.189

Guanjie Wang, Guobin Hu

College of Marine Life Sciences, Ocean University of China Institute of Evolution & Marine Biodiversity, Ocean University of China


The immune defense mechanism mainly depends on the recognition and response of innate immune signaling receptors PRRs to PAMPs or DAMPs. TLRs family is an important category in PRRs, stimulatory cytokines and interferon type I (IFN) are produced through TRIF-or MyD88-dependent after TLRs recognition PAMPs or DAMPs, which regulate innate and adaptive immunity responses. TLR3 only relies on the TRIF-dependent pathway for downstream signaling, TLR4 can conduct downstream signaling through both TRIF- and MyD88-dependent pathways. Teleosts TLR3 detects viral and additionally bacterial PAMPs, while TLR3-mediated activation of mammalian immune responses only depends on viral double-stranded RNA intermediates. Teleost TLR4 is suggested to down-regulate TLR signaling and/or to interact with alternative receptors such as b2-integrins, whereas mammalian TLR4 associates with CD14 and MD2 in order to sense LPS. In this review, we will further study the structure of TRIF, the TRIF-dependent signaling pathway, and its function in fish, with emphasis on the TRIF-dependent signaling pathway and different biological activities. The study of TRIF and its role in innate immunity has potential significance for the prevention and treatment of fish diseases.


TRIF, TRIF-dependent pathway, signal transduction, TLR3&4, teleost


The Fundamental Research Funds for the Central Universities (201822025, 201762003) and Shandong Provincial Natural Science Foundation (ZR2019MC051)


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