Epstein-Barr Virus Positive T-Cell Lymphoproliferative Disorder：One Case and a Short Literature Review
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v7i2.5282
Abstract
This report delineates a rare case of Epstein-Barr Virus-Positive T-Cell Lymphoproliferative Disorder (EBV+T-LPD), which represents a disease spectrum encompassing entities from indolent cutaneous forms to aggressive systemic lymphomas. This case concerns an 85-year-old male who presented with a four-month history of recurrent rash, fever, and localized lymphadenopathy. Notably, this elderly male patient exhibited cutaneous‑limited involvement and demonstrated a favorable prognosis-an outcome rarely documented in previous literature, and to the best of our knowledge, this represents the oldest case reported to date. Additionally, a review of published literature on adult‑onset EBV⁺ T‑LPD presenting with cutaneous manifestations is also provided.
Keywords
Epstein-Barr Virus-Positive T-Cell Lymphoproliferative Disorder; EBV; elderly; case summary
Full Text
PDF - Viewed/Downloaded: 0 TimesReferences
[1]WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer; 2024.
[2]Wongwiwat W, Fournier B, Bassano I, Bayoumy A, Elgueta Karstegl C, Styles C, Bridges R, Lenoir C, BoutBoul D, Moshous D, Neven B, Kanda T, Morgan RG, White RE, Latour S, Farrell PJ. Epstein-Barr Virus Genome Deletions in Epstein-Barr Virus-Positive T/NK Cell Lymphoproliferative Diseases. J Virol. 2022 Jun 22;96(12):e0039422.
[3]Rodriguez R, Fournier B, Cordeiro DJ, Winter S, Izawa K, Martin E, Boutboul D, Lenoir C, Fraitag S, Kracker S, Watts TH, Picard C, Bruneau J, Callebaut I, Fischer A, Neven B, Latour S. Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells. J Exp Med. 2019 Dec 2;216(12):2800-2818.
[4]Keam SJ. Tabelecleucel: First Approval. Mol Diagn Ther. 2023 May;27(3):425-431.
[5]De Mel S, Tan JZ, Jeyasekharan AD, Chng WJ, Ng SB. Transcriptomic Abnormalities in Epstein Barr Virus Associated T/NK Lymphoproliferative Disorders. Front Pediatr. 2019 Jan 17;6:405.
[6]Ruan Y, Shen X, Shi R, et al. Hydroa Vacciniforme-like Lymphoproliferative Disorder Treated with Intravenous Immunoglobulin: Long-term Remission Without Haematopoietic Stem Cell Transplantation or Chemotherapy. Acta dermato-venereologica. 2020; 100: p adv00192.
[7]Cook E, Haacker L, Chandra S,et al.EBV-Associated T/NK-LPD Manifesting As HLH Cured By Nivolumab and Emapalumab, Avoiding the Need for Allogeneic HCT[J].Transplantation and Cellular Therapy, 2025, 31(2-Sup):S43.
[2]Wongwiwat W, Fournier B, Bassano I, Bayoumy A, Elgueta Karstegl C, Styles C, Bridges R, Lenoir C, BoutBoul D, Moshous D, Neven B, Kanda T, Morgan RG, White RE, Latour S, Farrell PJ. Epstein-Barr Virus Genome Deletions in Epstein-Barr Virus-Positive T/NK Cell Lymphoproliferative Diseases. J Virol. 2022 Jun 22;96(12):e0039422.
[3]Rodriguez R, Fournier B, Cordeiro DJ, Winter S, Izawa K, Martin E, Boutboul D, Lenoir C, Fraitag S, Kracker S, Watts TH, Picard C, Bruneau J, Callebaut I, Fischer A, Neven B, Latour S. Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells. J Exp Med. 2019 Dec 2;216(12):2800-2818.
[4]Keam SJ. Tabelecleucel: First Approval. Mol Diagn Ther. 2023 May;27(3):425-431.
[5]De Mel S, Tan JZ, Jeyasekharan AD, Chng WJ, Ng SB. Transcriptomic Abnormalities in Epstein Barr Virus Associated T/NK Lymphoproliferative Disorders. Front Pediatr. 2019 Jan 17;6:405.
[6]Ruan Y, Shen X, Shi R, et al. Hydroa Vacciniforme-like Lymphoproliferative Disorder Treated with Intravenous Immunoglobulin: Long-term Remission Without Haematopoietic Stem Cell Transplantation or Chemotherapy. Acta dermato-venereologica. 2020; 100: p adv00192.
[7]Cook E, Haacker L, Chandra S,et al.EBV-Associated T/NK-LPD Manifesting As HLH Cured By Nivolumab and Emapalumab, Avoiding the Need for Allogeneic HCT[J].Transplantation and Cellular Therapy, 2025, 31(2-Sup):S43.
Copyright © 2026 Ranran Zhang, Jiaming Dong, Liyun Zheng, Ying Fang, Fang Wang, Min Gao
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License