Effect of Two Different Ventilation Methods on Ventilation Function in Preterm Infants during Recovery Period of RDS
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v7i1.5085
Abstract
Objective: To investigate the effects of two different ventilation methods on ventilation function in preterm infants with respiratory distress syndrome (RDS) during the recovery period. Methods: 100 preterm infants with respiratory distress syndrome (RDS) admitted to the neonatal intensive care unit of our hospital from January 2022 to January 2025 were selected as the study subjects. According to the random number table method, they were divided into high-frequency oscillatory ventilation combined with volume guarantee (HFOV-VG) group (50 cases) and conventional mechanical ventilation (CMV) group (50 cases). Compare the invasive mechanical ventilation time and total respiratory support time, arterial blood gas analysis results [arterial oxygen partial pressure (PaO₂), carbon dioxide partial pressure (PaCO₂), inspired oxygen fraction (FiO₂)], and the occurrence of adverse reactions between the two groups. Results: Both invasive mechanical ventilation time and total respiratory support time in HFOV-VG group were shorter than those in CMV group (P<0.05). The PaO₂ levels in the HFOV-VG group at 6h, 12h, and 24h were all lower than those in the CMV group (P<0.05). The PaCO₂ levels in the HFOV-VG group at 6h, 12h, and 24h were all lower than those in the CMV group (P<0.05). The FiO₂ levels in the HFOV-VG group at 30 minutes, 6 hours, 12 hours, and 24 hours were all lower than those in the CMV group (P<0.05). The incidence of hypocapnia, bronchopulmonary dysplasia, and intraventricular hemorrhage in the HFOV-VG group was significantly lower than that in the CMV group (P<0.05), and there was no difference in the incidence of other complications (P>0.05), but there was a tendency to decrease in the HFOV-VG group. Conclusion: HFOV-VG demonstrated significant advantages compared with CMV in the management of ventilatory function during the recovery period of RDS in preterm infants, including shortening ventilation time, improving oxygenation, and reducing the incidence of key complications.
Keywords
high-frequency oscillatory ventilation; volume guarantee; conventional mechanical ventilation; respiratory distress syndrome; preterm infants
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[3] Wang Yueyi, Wei Xuexu, Yin Haiwei, et al. Effect of volume guarantee high-frequency oscillatory ventilation on preterm infants with respiratory distress syndrome and its effect on cerebral blood flow in the middle cerebral artery [J].Chinese Journal of Contemporary Pediatrics, 2025, 27 (3):286-292.
[4] Solís-García G, Ramos-Navarro C, González-Pacheco N, et al. Lung protection strategy with high-frequency oscillatory ventilation improves respiratory outcomes at two years in preterm respiratory distress syndrome: a before and after, quality improvement study[J]. J Matern Fetal Neonatal Med,2022,35(26):10698-10705.
[5] Ru Xifang, Feng Qi. Prevention and treatment of neonatal respiratory distress syndrome-European Consensus Guidelines 2022 Edition [J]. Chinese Journal of Neonatology (Chinese and English), 2023, 38 (3):191-192.
[6] Dao Xinyue, Bao Lingyun, Du Kun. Guiding value of lung ultrasound in mechanical ventilation treatment of preterm infantswith respiratory distress syndrome [J]. Chinese Journal of Perinatal Medicine, 2025, 28 (11):944-949.
[7] Wang Luchun, Bao Zhidan, Ma Yizhe, et al. Prospective randomized controlled study of the efficacy of volume-assured high-frequency oscillatory ventilation on respiratory failure in preterm infantswith gestational age of 28 to 34 weeks [J].Chinese Journal of Contemporary Pediatrics, 2023, 25 (11):1101-1106.
[8] Chen Kai. Comparison of the effects of high-frequency oscillatory ventilation under volume assurance and normal-frequency mechanical ventilation in the treatment of neonatal respiratory distress syndrome [J]. Medical Journal of Chinese People's Health, 2024, 36 (3):153- 155, 159.
[9] Chen Zhiyun. Effect of high-frequency oscillatory ventilation in volume assurance mode in the treatment of neonatal respiratory distress syndrome [J]. Contemporary Medicine Forum, 2024, 22 (28):55-57.
[10] Yuan Jing, Li Shufang, Zhang Yuezhe, et al. Application of high-frequency and low-frequency volume in high-frequency oscillatory ventilation combined with volume assurance in the treatment of respiratory distress syndrome in preterm infants[J]. Journal of Developmental Medicine, 2023, 11 (2):112-118.
[11] Sheng Hao, Liu Chenglin, Sun Xiaofeng, et al. The value of transcranial Doppler ultrasound in the diagnosis of early vasospasm in patients with traumatic brain injury [J]. Journal of Imaging Research and Medical Applications, 2024,8(9):87-89.
[12] Li Yan, Wen Yuanxiang. Analysis of the influence of maternal and neonatal multi-dimensional factors on the risk and classification of bronchopulmonal dysplasia in preterm infants[J]. Chinese Journal of Woman and Child Health Research, 2025, 36 (8):84-90.
[13] Li Junxia, Xu Yuhao, Lu Chao, et al. Risk factors analysis of intraventricular hemorrhage in ultra- preterm infants[J]. Journal of Nanjing Medical University (Natural Science), 2023, 43 (7):990-994.
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