Nrf2 in Chronic Obstructive Pulmonary Disease: Research Progress
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v7i1.5077
Abstract
Nuclear factor erythroid 2-related factor 2 (Nrf2), a Cap'n'Collar basic leucine zipper transcription factor, regulates oxidative stress, inflammation, autophagy, metabolism, and immune responses. Chronic obstructive pulmonary disease (COPD), the most prevalent respiratory disorder in China, is marked by high morbidity and mortality, posing a substantial socioeconomic burden. This review examines Nrf2's role in COPD pathogenesis and progression through modulation of oxidative stress, ferroptosis, autophagy, and inflammatory response.
Keywords
Nrf2; chronic obstructive pulmonary disease; oxidative stress; inflammatory response; autophagy
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[4] Yamamoto M, Kensler TW, Motohashi H. The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. Physiol Rev. 2018 Jul 1;98(3):1169-1203. doi: 10.1152/physrev.00023.2017. PMID: 29717933; PMCID: PMC9762786.
[5] Kubo H, Asai K, Kojima K, et al. Exercise Ameliorates Emphysema Of Cigarette Smoke-Induced COPD In Mice Through The Exercise-Irisin-Nrf2 Axis [J]. Int J Chron Obstruct Pulmon Dis, 2019, 14: 2507-16.
[6] Kubo H, Asai K, Kojima K, Sugitani A, Kyomoto Y, Okamoto A, Yamada K, Ijiri N, Watanabe T, Hirata K, Kawaguchi T. Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema through Nrf2 Activation in Mice. Mar Drugs. 2019 Nov 28;17(12):673. doi: 10.3390/md17120673IF: 4.9 Q1 . PMID: 31795292; PMCID: PMC6950584.
[7] Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008 Mar;15(3):234-45. doi: 10.1016/j.chembiol.2008.02.010. PMID: 18355723; PMCID: PMC2683762.
[8] Lin W, Wang C, Liu G, Bi C, Wang X, Zhou Q, Jin H. SLC7A11/xCT in cancer: biological functions and therapeutic implications. Am J Cancer Res. 2020 Oct 1;10(10):3106-3126. PMID: 33163260; PMCID: PMC7642655.
[9] Wang Y, Tang M. PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance. Environ Pollut. 2019 Nov;254(Pt A):112937. doi: 10.1016/j.envpol.2019.07.105. Epub 2019 Jul 30. Erratum in: Environ Pollut. 2021 May 1;276:113640. doi: 10.1016/j.envpol.2019.113640. PMID: 31401526.
[10] Liu X, Ma Y, Luo L, Zong D, Li H, Zeng Z, Cui Y, Meng W, Chen Y. Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway. Phytomedicine. 2022 Feb;96:153894. doi: 10.1016/j.phymed.2021.153894 Q1 . Epub 2021 Dec 14. PMID: 34942457.
[11] Liu Y, Levine B. Autosis and autophagic cell death: the dark side of autophagy. Cell Death Differ. 2015;22(3):367-376. doi:10.1038/cdd.2014.143
[12] Nakatogawa H. Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy. Essays Biochem. 2013;55:39-50. doi:10.1042/bse0550039IF: 5.6 Q1
[13] Hosaka Y, Araya J, Fujita Y, et al. Chaperone-Mediated Autophagy Suppresses Apoptosis via Regulation of the Unfolded Protein Response during Chronic Obstructive Pulmonary Disease Pathogenesis [J]. J Immunol, 2020, 205(5): 1256-67.
[14] Li M-y, Qin Y-q, Tian Y-g, et al. Effective-component compatibility of Bufei Yishen formula III ameliorated COPD by improving airway epithelial cell senescence by promoting mitophagy via the NRF2/PINK1 pathway [J]. BMC Pulmonary Medicine, 2022, 22(1).
[15] Fan X, Dong T, Yan K, et al. PM2.5 increases susceptibility to acute exacerbation of COPD via NOX4/Nrf2 redox imbalance-mediated mitophagy [J]. Redox Biol, 2023, 59: 102587.
[16] Sun Y, Liu Y, Guan X, et al. Atorvastatin inhibits renal inflammatory response induced by calcium oxalate crystals via inhibiting the activation of TLR4/NF-κB and NLRP3 inflammasome. IUBMB Life. 2020;72(5):1065-1074. doi:10.1002/iub.2250.
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