Observation on the Clinical Efficacy of Zuojin Yifan Granules in the Treatment of Reflux Esophagitis (Liver Stomach Stagnation Heat Syndrome)
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v7i1.5066
Abstract
Objective: To observe the clinical efficacy of Zuojin Yifan Granules in the treatment of reflux esophagitis (liver stomach stagnation heat syndrome). Method: 108 patients with reflux esophagitis (liver stomach stagnation heat syndrome) were randomly divided into Group A, Group B, and Group C using a random number table, with 36 patients in each group. Group A received treatment with Zuojin Yifan Granules, Group B received treatment with Zuojin Yifan Granules combined with rabeprazole, and Group C received treatment with rabeprazole for 8 weeks. Clinical symptom scores between groups and within groups were compared, and the improvement of clinical symptoms and changes in esophageal mucosa under endoscopy were observed in patients. Result: Before treatment, there was no statistically significant difference in clinical symptom scores among the three groups (P>0.05). After treatment, the clinical symptom scores of the three groups improved compared to before treatment. The clinical symptom scores of Group B were lower than those of Group A and Group C (P<0.05), and the clinical symptom scores of Group A were lower than those of Group C (P<0.05). The total effective rate of clinical symptom improvement in Group B was higher than that in Group A (P<0.05), and the total effective rate of clinical symptom improvement in Group A after treatment was higher than that in Group C (P<0.05). The total effective rate of endoscopic efficacy in Group B was higher than that in Group A (P<0.05), and the total effective rate of endoscopic efficacy in Group A was higher than that in Group C (P<0.05). Conclusion: The clinical effect of Zuojin Yifan Granules in the treatment of reflux esophagitis (liver stomach stagnation heat syndrome) is ideal, which can significantly improve clinical symptoms and enhance the endoscopic efficacy of patients.
Keywords
Zuojin Yifan Granules, reflux esophagitis, liver and stomach stagnation heat syndrome
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[10] Wang Lina. Clinical Study on the Treatment of Reflux Esophagitis (Liver-Stomach Heat Stagnation Pattern) with Modified Chaihu Shugan Powder Combined with Zuojin Pill [J]. Inner Mongolia Journal of Traditional Chinese Medicine, 2025, 44(6): 55-56.
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[13] Liu Lili. Advances in Modern Pharmacological Effects, Dosage Form Design, and Clinical External Application Research of Evodia [J]. Journal of Chinese Medicine, 2025, 43(6): 52-60.
[14] Lu Jingfeng, Gu Qianxi, Yang Chen, et al. Advances in Research on the Pharmacological Effects and Mechanisms of Active Components and Effective Ingredients in Atractylodes Macrocephala [J]. Research on Special Products. 2025.082.
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[16] Gong Yuanxiang, Yan Xin, Zeng Yijia, et al. Research Progress on Chemical Constituents and Pharmacological Activities of Chenpi [J]. Guangdong Chemical Industry, 2024, 51(20): 96-98.
[17] Zhang Yiqing. Prediction Analysis of Chemical Constituents, Pharmacological Effects, and Quality Markers of Dandelion [J]. Journal of Liaoning University of Traditional Chinese Medicine. 2025, 27(2): 59-67.
[18] Jiang Baorui. Advances in Pharmacological Research on Trifoliate Orange [J]. Journal of Yunnan Traditional Chinese Medicine and Chinese Medicine, 2022, 43(6):70-75.
[19] Chen Yutong. Research Progress on Chemical Constituents and Pharmacological Effects of Zhebeimu and Its Predictive Analysis of Quality Markers [J]. Chinese Medicine Information, 2024, 41(6): 60-75.
[20] Mu Kailang. Quality Marker Research of Bletilla Striata Preparations Based on Fingerprint Spectra-Chemometric Analysis-Network Pharmacology [J]. Chinese Herbal Drugs and Clinical Pharmacology, 2023, 34(3): 404-413.
[21] Qin Ling, Hong Liangshuang. Advances in Pharmacological Effects and Clinical Applications of Panax Notoginseng [J]. Zhuang-Yao Medicine Research, 2023,(02):337-340.
[22] Zhong Gansheng. Pharmacology of Traditional Chinese Medicine [M]. 10th ed. Beijing: China Traditional Chinese Medicine Press, 2016.
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