Research Progress on the Role of Plant-Derived Natural Molecules in Inhibiting the Metastasis of Colorectal Cancer Cells
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i4.4823
Abstract
Colorectal cancer is a common and deadly cancer, with metastasis being the primary cause of its lethality. Traditional chemotherapy drugs are highly toxic to normal cells, necessitating the development of new therapies. Plant-derived natural molecules have shown significant potential in preventing and treating colorectal cancer metastasis, offering advantages over chemotherapy, such as lower toxicity, fewer side effects, and higher efficacy. Further research is crucial to identify novel natural compounds for treating colorectal cancer metastasis. While extensive reviews exist on plant-based drugs for cancer, few focus on colorectal cancer metastasis. This review highlights several promising plant-derived compounds with potential clinical applications.
Keywords
colorectal cancer, metastasis, plant-derived molecules, chemotherapy, clinical applications
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[1]Bray, F., et al., "Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries," CA: a cancer journal for clinicians, 68, 394-424 (2018).
[2]van der Geest, L. G., et al., "Nationwide trends in incidence, treatment and survival of colorectal cancer patients with synchronous metastases," Clinical & experimental metastasis, 32, 457-465 (2015).
[3]C. Focaccetti et al., Polyphenols as Immunomodulatory Compounds in the Tumor Microenvironment: Friends or Foes? International journal of molecular sciences 20, (2019).
[4]B. B. Aggarwal, L. Deb, S. Prasad, Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules (Basel, Switzerland) 20, 185-205 (2014).
[5]Y. H. Hsiao et al., Pterostilbene Inhibits Adipocyte Conditioned-Medium-Induced Colorectal Cancer Cell Migration through Targeting FABP5-Related Signaling Pathway. Journal of agricultural and food chemistry 67, 10321-10329 (2019).
[6]Y. R. Li, S. Li, C. C. Lin, Effect of resveratrol and pterostilbene on aging and longevity. BioFactors (Oxford, England) 44, 69-82 (2018).
[7]Y. W. Zhuang et al., Solasodine reverses stemness and epithelial-mesenchymal transition in human colorectal cancer. Biochemical and biophysical research communications 505, 485-491 (2018).
[8]Y. Li et al., Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway. Biochemical pharmacology 88, 150-157 (2014).
[9]L. Zhou et al., Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer. Oncology reports 43, 1159-1168 (2020).
[10]Q. Song et al., Tanshinone IIA Inhibits Epithelial-to-Mesenchymal Transition Through Hindering β-Arrestin1 Mediated β-Catenin Signaling Pathway in Colorectal Cancer. Frontiers in pharmacology 11, 586616 (2020).
[11]N. K. Roy et al., An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases. International journal of molecular sciences 20, (2019).
[12]I. Naz, S. Ramchandani, M. R. Khan, M. H. Yang, K. S. Ahn, Anticancer Potential of Raddeanin A, a Natural Triterpenoid Isolated from Anemone raddeana Regel. Molecules (Basel, Switzerland) 25, (2020).
[13]Y. Xu, G. Xu, L. Liu, D. Xu, J. Liu, Anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in Ls174-T cells. Journal of cellular biochemistry 111, 370-379 (2010).
[14]Y. Li et al., Modified apple polysaccharides could induce apoptosis in colorectal cancer cells. Journal of food science 75, H224-229 (2010).
[15]D. Zhang et al., Modified apple polysaccharides suppress the migration and invasion of colorectal cancer cells induced by lipopolysaccharide. Nutrition research (New York, N.Y.) 33, 839-848 (2013).
[2]van der Geest, L. G., et al., "Nationwide trends in incidence, treatment and survival of colorectal cancer patients with synchronous metastases," Clinical & experimental metastasis, 32, 457-465 (2015).
[3]C. Focaccetti et al., Polyphenols as Immunomodulatory Compounds in the Tumor Microenvironment: Friends or Foes? International journal of molecular sciences 20, (2019).
[4]B. B. Aggarwal, L. Deb, S. Prasad, Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules (Basel, Switzerland) 20, 185-205 (2014).
[5]Y. H. Hsiao et al., Pterostilbene Inhibits Adipocyte Conditioned-Medium-Induced Colorectal Cancer Cell Migration through Targeting FABP5-Related Signaling Pathway. Journal of agricultural and food chemistry 67, 10321-10329 (2019).
[6]Y. R. Li, S. Li, C. C. Lin, Effect of resveratrol and pterostilbene on aging and longevity. BioFactors (Oxford, England) 44, 69-82 (2018).
[7]Y. W. Zhuang et al., Solasodine reverses stemness and epithelial-mesenchymal transition in human colorectal cancer. Biochemical and biophysical research communications 505, 485-491 (2018).
[8]Y. Li et al., Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway. Biochemical pharmacology 88, 150-157 (2014).
[9]L. Zhou et al., Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer. Oncology reports 43, 1159-1168 (2020).
[10]Q. Song et al., Tanshinone IIA Inhibits Epithelial-to-Mesenchymal Transition Through Hindering β-Arrestin1 Mediated β-Catenin Signaling Pathway in Colorectal Cancer. Frontiers in pharmacology 11, 586616 (2020).
[11]N. K. Roy et al., An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases. International journal of molecular sciences 20, (2019).
[12]I. Naz, S. Ramchandani, M. R. Khan, M. H. Yang, K. S. Ahn, Anticancer Potential of Raddeanin A, a Natural Triterpenoid Isolated from Anemone raddeana Regel. Molecules (Basel, Switzerland) 25, (2020).
[13]Y. Xu, G. Xu, L. Liu, D. Xu, J. Liu, Anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in Ls174-T cells. Journal of cellular biochemistry 111, 370-379 (2010).
[14]Y. Li et al., Modified apple polysaccharides could induce apoptosis in colorectal cancer cells. Journal of food science 75, H224-229 (2010).
[15]D. Zhang et al., Modified apple polysaccharides suppress the migration and invasion of colorectal cancer cells induced by lipopolysaccharide. Nutrition research (New York, N.Y.) 33, 839-848 (2013).
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