Research Progress of Omentin-1 in Disease Diagnosis: A Review
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i4.4821
Abstract
Omentin-1, an adipokine secreted by visceral adipose tissue, plays a key role in various diseases by regulating insulin sensitivity, inflammation, and vascular health. Its diagnostic value is increasing, although challenges remain due to limited standardization and an incomplete understanding of its mechanisms. These challenges highlight the need for further research to improve its clinical application for the early detection and prognosis of metabolic and inflammatory conditions.
Keywords
Omentin-1, disease diagnosis, biomarker, metabolic diseases, cardiovascular diseases, inflammation
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[11] Li TL, Zhu NN, Zhao MX, et al. Omentin-1 attenuates atrial fibrillation via Src/PI3K/Akt signaling-mediated anti-fibrotic effects in cardiac fibroblasts.Eur J Pharmacol.996:177588.doi:10.1016/j.ejphar.2025.177588 https://pubmed.ncbi.nlm.nih.gov/40187594/
[12] Niu X, Cheng Y, Zhang M, et al. Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells.Front Cell Dev Biol.9:784035.Published 2021 None.doi:10.3389/fcell.2021.784035 https://pubmed.ncbi.nlm.nih.gov/35141232/
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[15] Baig M, Gazzaz ZJ, Bakarman MA, Alzahrani SH.Correlation of Serum Vaspin, Omentin-1, and adiponectin with metabolic phenotypes in Type-2 diabetes mellitus patients.Pak J Med Sci.2021 Nov-Dec;37(7):1762-1767.doi:10.12669/pjms.37.7.4330 https://pubmed.ncbi.nlm.nih.gov/34912392/
[16] Eimal Latif AH, Anwar S, Gautham KS, et al. Association of Plasma Omentin-1 Levels With Diabetes and Its Complications.Cureus.2021;13(9):e18203.Published 2021 Sep. doi:10.7759/cureus.18203 https://pubmed.ncbi.nlm.nih.gov/34703702/
[17] Biscetti F, Nardella E, Bonadia N, et al. Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease.Cardiovasc Diabetol.2019;18(1):74.Published 2019 Jun 5.doi:10.1186/s12933-019-0880-7 https://pubmed.ncbi.nlm.nih.gov/31167666/
[18] Devi S, Sahu S, Behera K, Priyadarshini N, Sahoo D.Assessment of Serum Omentin-1 and Interleukin-6 in the Diagnosis of Early Stages of Diabetic Nephropathy: A Cross-Sectional Observational Study.Cureus.2024;16(7):e64239.Published 2024 Jul. doi:10.7759/cureus.64239 https://pubmed.ncbi.nlm.nih.gov/39131026/
[19] Jin Z, Xia F, Dong J, et al. Omentin-1 attenuates glucocorticoid-induced cardiac injury by phosphorylating GSK3β.J Mol Endocrinol.2021;66(4):273-283.Published 2021 Apr 22.doi:10.1530/JME-20-0236 https://pubmed.ncbi.nlm.nih.gov/33739937/
[20] Leandro A, Queiroz M, Azul L, Seiça R, Sena CM.Omentin: A novel therapeutic approach for the treatment of endothelial dysfunction in type 2 diabetes.Free Radic Biol Med.162:233-242.doi:10.1016/j.freeradbiomed.2020.10.021 https://pubmed.ncbi.nlm.nih.gov/33099000/
[21] Komosinska-Vassev K, Olczyk P, Kuźnik-Trocha K, et al. Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy.J Clin Med.2019;8(6).Published 2019 Jun 5.doi:10.3390/jcm8060805 https://pubmed.ncbi.nlm.nih.gov/31195747/
[22] Gao K, Su Z, Meng J, et al. Effect of Exercise Training on Some Anti-Inflammatory Adipokines, High Sensitivity C-Reactive Protein, and Clinical Outcomes in Sedentary Adults With Metabolic Syndrome.Biol Res Nurs.2024;26(1):125-138.doi:10.1177/10998004231195541 https://pubmed.ncbi.nlm.nih.gov/37579279/
[23] Sperling M, Grzelak T, Pelczyńska M, Bogdański P, Formanowicz D, Czyżewska K.Association of Serum Omentin-1 Concentration with the Content of Adipose Tissue and Glucose Tolerance in Subjects with Central Obesity.Biomedicines.2023;11(2).Published 2023 Jan 24.doi:10.3390/biomedicines11020331 https://pubmed.ncbi.nlm.nih.gov/36830868/
[24] Cetin Sanlialp S, Nar G, Nar R.Relationship between circulating serum omentin-1 levels and nascent metabolic syndrome in patients with hypertension.J Investig Med.2022;70(3):780-785.doi:10.1136/jim-2021-002071 https://pubmed.ncbi.nlm.nih.gov/34857627/
[25] Karvane HB, Esfandiari H, Qutaiba O, et al. Metabolic syndrome in association with novel dietary index, metabolic parameters, nesfatin-1 and omentin-1.BMC Endocr Disord.2024;24(1):257.Published 2024 Nov 27.doi:10.1186/s12902-024-01791-2 https://pubmed.ncbi.nlm.nih.gov/39604989/
[26] Alanya Tosun Ş, Gurbuz T, Cebi A, Tosun A, Gokmen O, Usta M.Association of increased levels of omentin-1 and carotid intima-media thickness with early signs of cardiovascular risk in patients with polycystic ovary syndrome: A prospective case control study.J Obstet Gynaecol Res.2022;48(1):169-177.doi:10.1111/jog.15077 https://pubmed.ncbi.nlm.nih.gov/34676949/
[27] Çelik M, Nar R, Nar G, Sökmen E, Günver G.Serum omentin-1 levels in hypertensive patients.J Hum Hypertens.2021;35(3):290-295.doi:10.1038/s41371-020-00420-4 https://pubmed.ncbi.nlm.nih.gov/32978495/
[28] Zengi S, Zengi O, Kirankaya A, Kucuk SH, Kutanis EE, Yigit O.Serum omentin-1 levels in obese children.J Pediatr Endocrinol Metab.2019;32(3):247-251.doi:10.1515/jpem-2018-0231 https://pubmed.ncbi.nlm.nih.gov/30817300/
[29] Dogdus M, Dindas F, Cekici Y, et al. Association between Circulating Omentin-1 Levels and Aortic Valve Sclerosis.Acta Cardiol Sin.2022;38(5):584-590.doi:10.6515/ACS.202209_38(5).20220314A https://pubmed.ncbi.nlm.nih.gov/36176363/
[30] Neumayr G, Engler C, Lunger L, Lechleitner P.Effects of a One-week Vacation with Various Activity Programs on Metabolism and Adipokines.Int J Sports Med.2021;42(8):703-707.doi:10.1055/a-1297-4669 https://pubmed.ncbi.nlm.nih.gov/33260249/
[31] Özkan EA, Sadigov A, Öztürk O.Evaluation of Serum Omentin-1, Vaspin, Leptin, Adiponectin Levels in Obese/Overweight Children and Their Relationship With Non-Alcoholic Fatty Liver Disease.Clin Nutr Res.2022;11(3):194-203.Published 2022 Jul. doi:10.7762/cnr.2022.11.3.194 https://pubmed.ncbi.nlm.nih.gov/35949560/
[32] Ren Y, Zhao H, Yin C, et al. Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.Front Endocrinol (Lausanne).13:873699.Published 2022 None.doi:10.3389/fendo.2022.873699 https://pubmed.ncbi.nlm.nih.gov/35909571/
[33] Tian M, Cao J, Li M, et al. Associations of circulating omentin-1 levels and long noncoding RNA MALAT1 expression with coronary heart disease in patients with type 2 diabetes mellitus.Sci Rep. 2025;15(1):16376.Published 2025 May 11.doi:10.1038/s41598-025-01153-5 https://pubmed.ncbi.nlm.nih.gov/40350526/
[34] Lin S, Li X, Zhang J, Zhang Y.Omentin-1: Protective impact on ischemic stroke via ameliorating atherosclerosis.Clin Chim Acta.517:31-40.doi:10.1016/j.cca.2021.02.004 https://pubmed.ncbi.nlm.nih.gov/33607071/
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