Analysis of Medication in 3925 Outpatient Prescriptions Containing Traditional Chinese Medicine Toosendan Fructus
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i4.4811
Abstract
This study investigates the clinical application and safety of Toosendan Fructus to provide evidence for its rational use in practice. A total of 3,925 outpatient prescriptions containing Toosendan Fructus were collected from January to December 2023 at Guangzhou Hospital of Integrated Chinese and Western Medicine. Data on patient demographics, diagnosis, department distribution, dosage, and herb combinations were analyzed. Among 2,951 patients, 1,697 were female (1.35 times that of male). Most patients (52.18%) were aged 19–44 years. The Liver disease department prescribed the most Toosendan Fructus (28.87%), primarily for liver stagnacy (22.52%). Stir-fried Toosendan Fructus was used in 95.18% of prescriptions, with 64.84% exceeding the Chinese Pharmacopoeia limit (>10 g). Common combinations included Paeoniae Radix Alba, Bupleuri Radix, and vinegar-processed Rhizoma Corydalis. Stir-frying and compatible use of Chinese materia medica can reduce the toxicity of Toosendan Fructus. However, an audit system for off-label use and enhanced medication monitoring are recommended to ensure clinical safety.
Keywords
Toosendan Fructus; analysis on prescription medication; rational medication
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[3] Li HB, Ma SJ, Shi DF, et al. Research progress on chemical constituents, pharmacological action and toxicity of Melia toosendan [J]. Chin Tradit Herb Drugs, 2020, 51: 4059-4074.
[4] Zeng CH, Xing LR, Chen HP, et al. Principles of processing method reducing hepatotoxicity of Chuanlianzi (Toosendan Fructus): bioinformatics prediction and experiment validation. Chinese Archives of Traditional Chinese Medicine, 2025,43 (4):1-6.
[5] Standardization Administration of the People’s Republic of China. Clinic terminology of traditional Chinese medical diagnosis and treatment—Part 2:Syndromes/patterns[S]. 2021.
[6] Standardization Administration of the People’s Republic of China. Clinic terminology of traditional Chinese medical diagnosis and treatment—Part 1:Diseases[S]. 2023.
[7] Qin CC, Du QY, Zhang YM, et al. Historical evolution of processing and modern research progress of Toosendan Fructus [J]. Chinese Traditional Patent Medicine, 2023, 45(05): 1603-1609.
[8] Lou TT, Wu GQ, He JQ. Investigation and management of traditional Chinese medicine prescriptions containing Toosendan Fructus in outpatient and emergency departments of our hospital in 2023 [J]. Journal of Traditional Chinese Medicine Management, 2025, 33(16): 44-46.
[9] Zhuo S, Huang YF, Jiang C. Analysis of 500 outpatient prescriptions containing Toosendan Fructus in our hospital [J]. Strait Pharmaceutical Journal, 2019, 31(11): 125-127.
[10] Wang KY, Nie AZ. Discussion on pharmacology and toxicology of Toosendan Fructus and thoughts on rational medication [J]. Chinese Archives of Traditional Chinese Medicine, 2022, 40(03): 54-58.
[11] Fang XY, Ding QY, Yu TY, et al. Clinical application and dosage exploration of Toosendan Fructus [J]. Jilin Journal of Traditional Chinese Medicine, 2021, 41(07): 939-942.
[12] Yan X, Yue GC, Xiao YY. A brief analysis of the detoxification effects of Paeoniae Radix Alba in combination with different Chinese herbs [J]. China's Naturopathy, 2021, 29(06): 73-76.
[13] She YP, Zhang PP, Hu JY, et al. Exploration on the precise application of Bupleurum Chinense and Bupleurum Scorzonerifolium in classical prescriptions [J]. China Journal of Chinese Materia Medica, 2023, 48(03): 681-688.
[14] Wang CF, Yang JY, Xiao BK, et al. Comparison of analgesic and anti-inflammatory effects of the compound JinlingziSan and its single herbs [J]. Science Technology and Engineering, 2018, 18(24): 209-212.
Copyright © 2026 Rongfan Wang, Meifang Liang, Wanting Li, Jie Yang, Huifang Ma, Yunli Yang, Qian Ma, Min Fan, Jiamei Ma, Junyan Zou
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License