Research Progress of Atopic Dermatitis in Traditional Chinese and Western Medicine
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i4.4808
Abstract
Atopic dermatitis (AD), also known as atopic eczema, is a chronic, relapsing, inflammatory skin disease. Its etiology is not yet fully understood, but it is believed to be associated with various external factors, including genetics, immune dysregulation, environmental influences, and skin barrier dysfunction. By reviewing the literature, this article summarizes the pathogenesis, triggering factors, and integrated traditional Chinese and Western medicine treatment approaches, aiming to provide the latest research progress for the treatment of AD.
Keywords
atopic dermatitis; integrated traditional Chinese and Western medicine; efficacy; research progress
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[22] Zhou Yaxun, Liu Xiaoguang, Li Tan, et al. Application of immunosuppressive agents in atopic dermatitis [J]. Journal of Medical Science of the Armed Police Logistics College, 2013, 22(04): 341–344.
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[24] Zhang Hanwen, Gu Qinwufeng, Wang Dongming, et al. Research progress on the pathogenesis of atopic dermatitis from the perspective of skin microecology [J]. Clinical Journal of Medical Officers, 2024, 52(08): 872–875.
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[26] Liu Xinxin, Guan Zhiwei, Lin Yangyang, et al. Research progress on genetic factors in atopic dermatitis [J]. Chinese Journal of Practical Pediatrics, 2023, 38(09): 669–674.
[27] Bian Yawei, Li Qinfeng. Research progress on gene mutations related to skin barrier disruption in atopic dermatitis [J]. Dermatology and Venereology, 2022, 44(02): 126–128.
[28] Sun Zhizhong, Liu Chaohong. Study on the efficacy of Winona moisturizer in treating atopic dermatitis and its effect on skin barrier function [J]. Chinese Journal of Aesthetic Medicine, 2018, 27(11): 49–52.
[29] Chen Mengxue, Yao Ciyu, Zhang Jing, et al. Clinical effect of Qingre Lishi Decoction combined with Zicao ointment in treating infantile atopic dermatitis with damp-heat accumulation syndrome [J]. Journal of Medical Theory and Practice, 2025, 38(04): 632–634.
[2] Tang Chuanyi, Yao Zhirong. Role of early and regular use of moisturizers in the prevention and treatment of neonatal atopic dermatitis [J]. Journal of Clinical Pediatrics, 2024, 42(09): 817–821.
[3] Ogulur I, Mitamura Y, Yazici D, et al. Type 2 immunity in allergic diseases. Cell Mol Immunol. 2025;22:211–242.
[4] Zhu Chenxi, Yao Zhirong. Role of Langerhans cells in the immune mechanism and treatment of atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(10): 631–635.
[5] Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, et al. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.
[6] Chapman S, Kwa M, Gold LS, Lim HW. Janus kinase inhibitors in dermatology: Part I. A comprehensive review.
[7] Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O'Shea JJ. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.
[8] Morris R, Kershaw NJ, Babon JJ. The molecular details of cytokine signaling via the JAK/STAT pathway.
[9] Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, et al. Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis.
[10] Amano W, Nakajima S, Kunugi H, Numata Y, Kitoh A, Egawa G, et al. The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling.
[11] Li Sida, Li Xinhong. Clinical research progress of acupuncture in the treatment of atopic dermatitis [J/OL]. Journal of Practical Traditional Chinese Internal Medicine, 1–5 [2025-02-28].
[12] Chen Guangxian, Lin Guohua, Wang Shuxin, et al. Therapeutic observation of Lingnan fire acupuncture combined with medication in the treatment of adult atopic dermatitis [J]. Shanghai Journal of Acupuncture and Moxibustion, 2023, 42(06): 634–638.
[13] Wang Li, Zhao Linye, Zheng Huidan, et al. Research progress of cotton moxibustion in the treatment of skin diseases [J]. Chinese Journal of Traditional Medical Science and Technology, 2024, 31(02): 379–381.
[14] Yao Rong, Li Yuanwen, Hu Bo, et al. Efficacy of modified Guomin Decoction combined with dupilumab in treating atopic dermatitis patients with wind-dampness skin syndrome and its effect on peripheral blood T cell subsets [J]. Journal of Clinical and Experimental Medicine, 2025, 24(01): 107–111.
[15] Su Zhanbao, Yuan Liqiong, Zhou Xiaoyun, et al. Therapeutic observation of Qufeng Baidu Powder in treating atopic dermatitis of wind-dampness-heat toxin type [J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2024, 33(18): 2575–2579.
[16] Ding Weifang, Zhang Ning, Meng Xiaohui. Effect of Jianpi Yangxue Qufeng Decoction combined with mometasone furoate cream in treating atopic dermatitis patients with blood deficiency and wind-dryness syndrome [J]. Chinese Journal of MinKang Medicine, 2025, 37(01): 130–133.
[17] Wang Zhimin, Qin Cheng, Yang Xianna, et al. Clinical efficacy and experimental study of modified Xiaoyao Powder in the treatment of atopic dermatitis [J]. Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine, 2024, 23(05): 397–403.
[18] He Wei. Standardization of topical hormone therapy for atopic dermatitis [J]. China Medical Abstracts (Dermatology), 2016, 33(02): 184–188+92.
[19] Yang Sailin, Xu Aie. Dermatological applications of calcineurin inhibitors tacrolimus and pimecrolimus beyond atopic dermatitis [J]. Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine, 2018, 17(01): 91–94.
[20] Wang Yujia, Zhen Li, Wang Congmin, et al. Research progress of phototherapy in atopic dermatitis [J]. Journal of Practical Dermatology, 2023, 16(01): 42–44+50.
[21] Wu Jiang, Li Changxing, Xu Huiqing. Clinical observation of tacrolimus ointment combined with narrow-band UVB in the treatment of atopic dermatitis [J]. Journal of Diagnosis and Therapy on Dermato-venereology, 2013, 20(03): 182–183.
[22] Zhou Yaxun, Liu Xiaoguang, Li Tan, et al. Application of immunosuppressive agents in atopic dermatitis [J]. Journal of Medical Science of the Armed Police Logistics College, 2013, 22(04): 341–344.
[23] Chen Qianru, Shen Xiaofeng, Kang Xiaojing. New progress in biological agents for the treatment of atopic dermatitis [J]. Journal of Practical Dermatology, 2024, 17(01): 36–39+63.
[24] Zhang Hanwen, Gu Qinwufeng, Wang Dongming, et al. Research progress on the pathogenesis of atopic dermatitis from the perspective of skin microecology [J]. Clinical Journal of Medical Officers, 2024, 52(08): 872–875.
[25] Wang Wanni, Li Ying, Zeng Jiahui, et al. Research progress on the prevention and treatment of atopic dermatitis by probiotics and their mechanisms [J]. Acta Microbiologica Sinica, 2024, 64(05): 1378–1391.
[26] Liu Xinxin, Guan Zhiwei, Lin Yangyang, et al. Research progress on genetic factors in atopic dermatitis [J]. Chinese Journal of Practical Pediatrics, 2023, 38(09): 669–674.
[27] Bian Yawei, Li Qinfeng. Research progress on gene mutations related to skin barrier disruption in atopic dermatitis [J]. Dermatology and Venereology, 2022, 44(02): 126–128.
[28] Sun Zhizhong, Liu Chaohong. Study on the efficacy of Winona moisturizer in treating atopic dermatitis and its effect on skin barrier function [J]. Chinese Journal of Aesthetic Medicine, 2018, 27(11): 49–52.
[29] Chen Mengxue, Yao Ciyu, Zhang Jing, et al. Clinical effect of Qingre Lishi Decoction combined with Zicao ointment in treating infantile atopic dermatitis with damp-heat accumulation syndrome [J]. Journal of Medical Theory and Practice, 2025, 38(04): 632–634.
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