Indoor and Outdoor Exposure: Recent Advances in Research on Lung Cancer in Women and Its Association with Household Cooking Fumes, Secondhand Smoke, and PM2.5
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i4.4806
Abstract
This study provides important theoretical basis for etiological research and the development of prevention and control strategies for lung cancer in women. By systematically examining the independent and synergistic exposure effects of household cooking fumes, secondhand smoke, and PM2.5, the study overcomes the limitations of traditional single-factor research and, for the first time, reveals the environmental pathogenic mechanisms underlying the high incidence of lung cancer in non-smoking women from an integrated perspective of indoor and outdoor dual exposure. The study elucidates the synergistic carcinogenic effects of the three environmental factors through common pathways such as oxidative stress, DNA damage, chronic inflammation, and epigenetic changes, providing a new theoretical framework for explaining the lung cancer incidence risk in this special population of non-smoking women. These findings not only enrich environmental carcinogenesis theory but also lay a scientific foundation for developing targeted lung cancer prevention and control strategies for women, particularly providing critical theoretical support for individual protective measures and social intervention policies in high-risk environments.
Keywords
Female lung cancer, Environmental factors,Synergistic carcinogenesis,Oxidative stress,Prevention strategies
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[3]Chen Yinglan, Wan Hong. The incidence of lung cancer in women is rising rapidly; these risk factors should be taken seriously. China National Knowledge Infrastructure. 2022.
[4]Wu Mengru. The impact of kitchen fume exposure on the risk of lung cancer in non-smoking women and effective preventive measures. Anhui Medical University. 2024.
[5]Liu Shaowei. The main culprit behind lung cancer in Chinese women: kitchen fumes. Cancer Prevention and Control. 2021.
[6]Stadler R, Gastelum G, Chu C, et al. Molecular Mechanisms of Pulmonary Carcinogenesis by Polycyclic Aromatic Hydrocarbons (PAHs). Semin Cancer Biol. 2021;76:3-16.
[7]Ma Y, Deng L, Ma P, et al. In Vivo Respiratory Toxicology of Cooking Oil Fumes. J Hazard Mater. 2021;402:123455.
[8]Li Y, Xu H, Wang J, et al. Personal Exposure to PM2.5-Bound Organic Species from Domestic Solid Fuel Combustion. Chemosphere. 2019;227:53-62.
[9]Hecht SS. Recent Studies on Mechanisms of Bioactivation and Detoxification of 4-(Methylnitrosamine)-1-(3-Pyridyl)-1-Butanone (NNK). Crit Rev Toxicol. 1996;26(2):163-181.
[10]Ye Xiu, Xu Ning. Meta-analysis of cohort studies on the association between passive smoking and lung cancer in non-smoking women. Journal of Environmental Health. 2022.
[11] Xue Y, Wang L, Zhang Y, et al. Air Pollution: A Culprit of Lung Cancer. J Hazard Mater. 2022;434:128937.
[12]Li J, Li WX, Bai C, et al. Particulate Matter-Induced Epigenetic Changes and Lung Cancer. Clin Respir J. 2017;11(5):539-546.
[13] Zhou Wei. The Role of Abnormal DNA Methylation Patterns in the Process of PM2.5-Induced Lung Cancer [D]. Beijing: Academy of Military Medical Sciences, People's Liberation Army of China, 2017.
[14]Guo T, Chen S, Wang Y, et al. Potential Causal Links of Long-Term Air Pollution with Lung Cancer Incidence. Int J Cancer. 2024;154(2):251-260.
[15] Shen S, Luo M, Meng X, et al. All-Cause Mortality Risk Associated With Solid Fuel Use Among Chinese Elderly People. Front Public Health. 2021;9:741637.
[16][19] Wang L, Xiang Z, Stevanovic S, et al. Role of Chinese Cooking Emissions on Ambient Air Quality and Human Health. Sci Total Environ. 2017;589:173-181.
[17] Corrales L, Rosell R, Cardona AF, et al. Lung Cancer in Never Smokers: The Role of Different Risk Factors Other Than Tobacco Smoking. Crit Rev Oncol Hematol. 2020;148:102895.
[18]Ding Shiyia, Guan Yun, Huang Xianghua, et al. Survey on Smoking and Secondhand Smoke Exposure Among Lung Cancer Patients and Their Attitudes Toward Smoking Bans in Public Places. South China Journal of Preventive Medicine. 2022.
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