Discussion on the Effect of Intestinal Flora Dysbiosis and Pyroptosis on Ascites Due to Liver Cirrhosis Based on the Theory of "Yang Transforming Qi, Yin Shaping"
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i4.4803
Abstract
Ascites due to cirrhosis is a serious complication of chronic liver disease progressing to the decompensated stage, which belongs to the category of "distention" in traditional Chinese medicine. It has the characteristics of high morbidity, high recurrence rate and high mortality, and its clinical treatment faces many limitations. Dysbiosis of intestinal flora and abnormal activation of pyroptosis have been proved to be important microscopic mechanisms of the pathogenesis of cirrhosis ascites in recent years. Both of them promote the disease progression through the gut liver axis and inflammation mediated pathways. Based on the theory of "Yang dissolves Qi and Yin forms" in Huangdi Neijing, it is believed that "insufficient Yang dissolves Qi and excessive Yin forms" is the core pathogenesis of liver cirrhosis ascites. Qi loss caused by deficiency of Yang Qi in liver, spleen and kidney is the root cause of the disease. Phlegm, blood stasis, water and moisture condensation and accumulation of pathological products at the microscopic level are the symptoms of the disease. Yin Yang disharmony and endogenous pathogens and toxins are the key links of disease progression. This paper deeply discusses the internal relationship between the theory of "Yang transforming Qi, Yin shaping" and the imbalance of intestinal flora and pyroptosis, combines the macro thinking of traditional Chinese medicine with modern micro mechanism, takes "Warming Yang transforming Qi, removing blood stasis and dispersing nodules" as the treatment principle, and provides new ideas for the prevention and treatment of cirrhosis ascites by regulating the balance of intestinal flora and inhibiting abnormal pyroptosis.
Keywords
cirrhosis ascites; Yang turns into gas and Yin forms; dysbiosis of intestinal flora; pyroptosis
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