Research Progress on the Correlation between miRNA and Tamoxifen Resistance in Breast Cancer
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i4.4802
Abstract
MicroRNA (miRNA) plays a crucial regulatory role in the mechanism of tamoxifen resistance in breast cancer. This article conducts a systematic review on the molecular mechanisms, clinical significance, and potential therapeutic strategies of miRNA regulating tamoxifen resistance in breast cancer. A variety of miRNAs exert promoting or inhibitory effects on the occurrence and development of tamoxifen resistance by targeting key molecules such as the estrogen receptor signaling pathway, apoptosis-related genes, and drug transporters. These miRNAs can not only serve as biomarkers for drug resistance but also become potential therapeutic targets for reversing drug resistance. A profound understanding of the miRNA-mediated drug resistance mechanism is of great significance for improving the prognosis of breast cancer patients.
Keywords
miRNA, breast cancer, tamoxifen resistance, research progress
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[3] Lei Z X, Yang H Y, Xie H, et al. Research Progress of miRNA in Breast Cancer [J]. Journal of Huazhong Agricultural University, 2024, 43(5): 149-156. (In Chinese)
[4] Sun L, Jiao W Y, Cui Q F, et al. tRF-Leu Reverses Breast Cancer Cells Chemoresistance by Regulation of BIRC5 [J]. Discover Oncology, 2024, 15(1): 449-449.
[5] Ding Y Z, Xia Z W, Yan Z, et al. Expression of Phosphatase and Tensin Homolog Deleted on Chromosome Ten on the Development of Cisplatin Resistance in Breast Cancer by TGF-beta(1) Signal Pathway [J]. Journal of Biomaterials and Tissue Engineering, 2021, 11(10): 1900-1907.
[6] Saliha M, Junaid D B, Khalid I, et al. Biofabricated Platinum Nanoparticles: Therapeutic Evaluation as a Potential Nanodrug against Breast Cancer Cells and Drug-Resistant Bacteria [J]. RSC Advances, 2021, 11(40): 24900-24916.
[7] Xiaochuan L, Jun Y, Xudong Z, et al. ATF3 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an N6-Methyladenosine-Based Epitranscriptomic Mechanism [J]. Chemical Research in Toxicology, 2021, 34(7): 1814-1821.
[8] Zhou L L, Shen M, Zhang Q Y. Effect of B7 Homolog 4 Molecule on miRNA Expression Profile of Breast Cancer Cells [J]. Journal of Fujian Medical University, 2024, 58(2): 82-92. (In Chinese)
[9] Zhou K, Tian B X, Yin X X, et al. Effect of miRNA-381 Regulating CCNA2 Expression on Proliferation, Migration and Prognosis of Breast Cancer [J]. Chinese Journal of Clinical Laboratory Science, 2022, 40(9): 667-672. (In Chinese)
[10] Rui X, K. H P, Jiong Z, et al. Lead Based Development and Evaluation of Selective Estrogen Mimics in Tamoxifen Resistant Breast Cancer [J]. Abstracts of Papers of the American Chemical Society, 2014, 248.
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