Study on the Preparation Process of Shegan Qingwen Fuzheng Oral Liquid
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i4.4715
Abstract
Objective — To investigate the preparation process of Shegan Qingwen Fuzheng Oral Liquid (SQFOL) to fully extract active components, enhance the content and stability of pharmacologically active constituents in the formulation, and ensure clinical efficacy. Methods — The extraction process for volatile components, β-cyclodextrin inclusion process for distillate, and extraction process for distillation residue were investigated separately. Results — The optimal extraction process for volatile components was determined as follows: 8-fold water volume, 1-hour soaking time, and 4-hour distillation time. The optimal β-cyclodextrin inclusion process for distillate was a core-to-shell mass ratio of 1:4, inclusion temperature of 40°C, and inclusion time of 2 hours. The extraction process for distillation residue was adding 8 times the volume of 50% ethanol, performing two extractions: the first for 2 hours and the second for 1.5 hours. Conclusions — The extraction processes were validated to be stable and feasible.
Keywords
Shegan Qingwen Fuzheng Oral Liquid; preparation process; volatile component extraction; inclusion process; reflux extraction
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[1]Zhao AQ, et al. Research progress on antiviral effects of traditional Chinese medicine. Shandong Chem Ind. 2020; 49(6).
[2]Guo CC, et al. The embodiment of the TCM principle "Fuzheng Quxie" in "Three Medicines and Three Formulas" for COVID-19 treatment. J Liaoning Univ Tradit Chin Med. 2020; 22(10): 159-163.
[3]Duan HJ, et al. Potential common effects and mechanisms of Qingfei Paidu Decoction on three coronavirus infections: SARS, MERS and COVID-19. Pharmacol Clin Chin Mater Med. 2020; 36(4): 29-35.
[4]Li XF, et al. Discussion on research ideas of pharmacodynamic material basis and mechanism of traditional Chinese medicine. J Guangzhou Univ Tradit Chin Med. 2020; 37(2): 366-370.
[5]Huang JW, Ma XY, Zhu MC, et al. Research progress on mechanism of traditional Chinese medicine against viral pneumonia based on "Fuzheng Quxie" principle. Acta Chin Med Pharmacol. 2022; 50(12): 97-101.
[6]Sun GX, Sun WY, Yan H, et al. Construction of overall quality control standard system for traditional Chinese medicine and steps for consistency evaluation. Cent South Pharm. 2019; 17(3): 321-331.
[7]Zhang L,Hu Y,Zhang J, et al. Application of chemical pattern recognition and similarity evaluation in electrochemical and HPLC-DAD fingerprints for quality consistency study of herbal medicines[J].Analytica Chimica Acta,2025,1349343830-343830.
[8]Ansah O J,Boateng R,Amuah Y L C, et al. Identification of Spectral Fingerprints in Different Batches of Antimalarial Herbal Drugs Using Laser-Induced Autofluorescence and Chemometric Techniques.[J].Journal of fluorescence,2025, (prepublish):1-9.
[2]Guo CC, et al. The embodiment of the TCM principle "Fuzheng Quxie" in "Three Medicines and Three Formulas" for COVID-19 treatment. J Liaoning Univ Tradit Chin Med. 2020; 22(10): 159-163.
[3]Duan HJ, et al. Potential common effects and mechanisms of Qingfei Paidu Decoction on three coronavirus infections: SARS, MERS and COVID-19. Pharmacol Clin Chin Mater Med. 2020; 36(4): 29-35.
[4]Li XF, et al. Discussion on research ideas of pharmacodynamic material basis and mechanism of traditional Chinese medicine. J Guangzhou Univ Tradit Chin Med. 2020; 37(2): 366-370.
[5]Huang JW, Ma XY, Zhu MC, et al. Research progress on mechanism of traditional Chinese medicine against viral pneumonia based on "Fuzheng Quxie" principle. Acta Chin Med Pharmacol. 2022; 50(12): 97-101.
[6]Sun GX, Sun WY, Yan H, et al. Construction of overall quality control standard system for traditional Chinese medicine and steps for consistency evaluation. Cent South Pharm. 2019; 17(3): 321-331.
[7]Zhang L,Hu Y,Zhang J, et al. Application of chemical pattern recognition and similarity evaluation in electrochemical and HPLC-DAD fingerprints for quality consistency study of herbal medicines[J].Analytica Chimica Acta,2025,1349343830-343830.
[8]Ansah O J,Boateng R,Amuah Y L C, et al. Identification of Spectral Fingerprints in Different Batches of Antimalarial Herbal Drugs Using Laser-Induced Autofluorescence and Chemometric Techniques.[J].Journal of fluorescence,2025, (prepublish):1-9.
Copyright © 2026 Zhifei Hou, Lifen Li, Weixian Guo, Lifang Liu, Yu Liu, Yunfei Xie
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