Integrative Network Pharmacology and Metabolomics Reveal the Anti-Tumor Mechanisms of Natural Compounds via HIF-1α-Mediated Glycolysis Reprogramming
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i2.4050
Abstract
This study investigates the anti-tumor mechanisms of natural compounds through hypoxia-inducible factor-1α (HIF-1α)-mediated glycolysis reprogramming by integrating network pharmacology and metabolomics. Utilizing multi-omics approaches, we mapped compound-target interactions and metabolic flux alterations in tumor models, revealing that natural compounds suppress HIF-1α signaling and downstream glycolytic enzymes (e.g., HK2, LDHA), thereby disrupting ATP production and lactate accumulation. Functional validation demonstrated that these compounds synergistically inhibit tumor proliferation and metastasis while enhancing chemosensitivity.
Keywords
natural compounds; HIF-1α; glycolysis reprogramming; network pharmacology-metabolomics integration
Full Text
PDF - Viewed/Downloaded: 2 TimesReferences
[1]Hu Y,Li J,Chen H, et al.Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90-HIF-1α-Mediated Glycolysis in Kidney Fibrosis.[J].Advanced science (Weinheim, Baden-Wurttemberg, Germany),2025,e2414673.
[2]Zhang X,Peng L,Kuang S, et al.Lactate accumulation from HIF-1α-mediated PMN-MDSC glycolysis restricts brain injury after acute hypoxia in neonates[J].Journal of Neuroinflammation,2025,22(1):59-59.
[3]Min F,Wang Z,Shao H, et al.Oral exposure to ovalbumin alters glucose metabolism in sensitized mice: upregulation of HIF-1α-mediated glycolysis.[J].Food & function,2024.
[4]Liu S,Zhang T,Fang L, et al.Integrative pharmacological analysis of modified Zuojin formula: inhibiting the HIF-1α-mediated glycolytic pathway in chronic atrophic gastritis.[J].Journal of ethnopharmacology,2024,339119136.
[5]Zhang Q,Qin Y,Sun X, et al.Sodium butyrate blocks the growth of colorectal cancer by inhibiting the aerobic glycolysis mediated by SIRT4/HIF-1α.[J].Chemico-biological interactions,2024,403111227.
[2]Zhang X,Peng L,Kuang S, et al.Lactate accumulation from HIF-1α-mediated PMN-MDSC glycolysis restricts brain injury after acute hypoxia in neonates[J].Journal of Neuroinflammation,2025,22(1):59-59.
[3]Min F,Wang Z,Shao H, et al.Oral exposure to ovalbumin alters glucose metabolism in sensitized mice: upregulation of HIF-1α-mediated glycolysis.[J].Food & function,2024.
[4]Liu S,Zhang T,Fang L, et al.Integrative pharmacological analysis of modified Zuojin formula: inhibiting the HIF-1α-mediated glycolytic pathway in chronic atrophic gastritis.[J].Journal of ethnopharmacology,2024,339119136.
[5]Zhang Q,Qin Y,Sun X, et al.Sodium butyrate blocks the growth of colorectal cancer by inhibiting the aerobic glycolysis mediated by SIRT4/HIF-1α.[J].Chemico-biological interactions,2024,403111227.
Copyright © 2025 Sijie Lu
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
