Mechanistic Research and Therapeutic Advances of the JAK/STAT Signaling Pathway in Myocardial Infarction

Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i1.3723

Fengming Lai1, Wenyu Xie1, Dewen Liu1, Ting Hu2, Taizhong Wang3, Yulian Tang3

1. Graduate School, Youjiang Medical University for Nationalities, Baise, Guangxi, China
2. Clinical Medical College of Youjiang Medical University for Nationalities, Baise, Guangxi, China
3. School of Medical Laboratory, Youjiang Medical University for Nationalities, Baise, Guangxi, China

Abstract

Myocardial infarction (MI) is a critical heart disease with high incidence and mortality. Current treatments like coronary reperfusion have limitations, including risks of reperfusion injury and bleeding. Understanding MI's molecular mechanisms is vital for developing new strategies. The JAK/STAT pathway plays a key role in MI by regulating inflammation, apoptosis, fibrosis, oxidative stress, and angiogenesis. This article reviews its role in MI pathophysiology and its therapeutic potential, laying a foundation for innovative treatments. As research progresses, modulating JAK/STAT shows promise in reducing myocardial damage and inflammation, offering hope for future effective therapies.

Keywords

janus kinase (JAK), signal transducer and activator of transcription (STAT), myocardial infarction (MI), therapeutic strategies

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Copyright © 2025 Fengming Lai, Wenyu Xie, Dewen Liu, Ting Hu, Taizhong Wang, Yulian Tang

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