Advancements in Non-Pharmacological Interventions for Mild Cognitive Impairment Induced by Alzheimer's Disease
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i1.3683
Abstract
Mild cognitive impairment (MCI) associated with Alzheimer's disease (AD) represents the initial clinical manifestation of AD. Early clinical intervention for MCI is crucial for delaying or potentially reversing the progression of AD. Given the increasing prevalence of population aging, AD, as the leading cause of dementia, has imposed significant social and familial burdens. Therefore, early identification, diagnosis, and intervention of AD are of paramount importance both clinically and socially. This review aims to summarize recent advancements in the clinical diagnosis and non-pharmacological treatment of MCI derived from AD, thereby enhancing understanding of this condition, providing valuable references for clinical practice, and ultimately improving patients' cognitive function and quality of life.
Keywords
Alzheimer's disease; Mild cognitive impairment; Non-drug therapy
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[5]Kawagoe T, Matsushita M, Hashimoto M, et al. Face-specific memory deficits and changes in eye scanning patterns among patients with amnestic mild cognitive impairment[J]. Scientific reports, 2017, 7(1): 14344.
[6]Kotwal A A, Kim J, Waite L, et al. Social function and cognitive status: Results from a US nationally representative survey of older adults[J]. Journal of general internal medicine, 2016, 31: 854-862.
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[14]Hardman R J, Meyer D, Kennedy G, et al. Findings of a pilot study investigating the effects of Mediterranean diet and aerobic exercise on cognition in cognitively healthy older people living independently within aged-care facilities: The Lifestyle Intervention in Independent Living Aged Care (LIILAC) Study[J]. Current developments in nutrition, 2020, 4(5): nzaa077.
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[16]Xiang S, Ji J L, Li S, et al. Efficacy and safety of probiotics for the treatment of Alzheimer's disease, mild cognitive impairment, and Parkinson's Disease: a systematic review and meta-analysis[J]. Frontiers in aging neuroscience, 2022, 14: 730036.
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[18]Wang S, Zheng X, Huang J, et al. Sleep characteristics and risk of Alzheimer’s disease: a systematic review and meta-analysis of longitudinal studies[J]. Journal of Neurology, 2024: 1-12.
[19]Fernandes M, Placidi F, Mercuri N B, et al. The importance of diagnosing and the clinical potential of treating obstructive sleep apnea to delay mild cognitive impairment and Alzheimer’s disease: a special focus on cognitive performance[J]. Journal of Alzheimer's Disease Reports, 2021, 5(1): 515-533.
[20]Sherman D S, Mauser J, Nuno M, et al. The efficacy of cognitive intervention in mild cognitive impairment (MCI): a meta-analysis of outcomes on neuropsychological measures[J]. Neurophysiology review, 2017, 27: 440-484.
[21]Stern Y, Arenaza‐Urquijo E M, Bartrés‐Faz D, et al. Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance[J]. Alzheimer's & Dementia, 2020, 16(9): 1305-1311.
[22]Chapman S B, Aslan S, Spence J S, et al. Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors[J]. Cerebral cortex, 2015, 25(2): 396-405.
[23]Chan A T C, Ip R T F, Tran J Y S, et al. Computerized cognitive training for memory functions in mild cognitive impairment or dementia: a systematic review and meta-analysis[J]. NPJ Digital Medicine, 2024, 7(1): 1.
[24]Son C, Park J H. Ecological effects of VR-based cognitive training on ADL and IADL in MCI and AD patients: a systematic review and meta-analysis[J]. International Journal of Environmental Research and Public Health, 2022, 19(23): 15875.
[25]Kim J H, Cho M R, Shin J C, et al. Factors contributing to cognitive improvement effects of acupuncture in patients with mild cognitive impairment: a pilot randomized controlled trial[J]. Trials, 2021, 22(1): 341.
[26]Pang Y, Shi M. Repetitive transcranial magnetic stimulation improves mild cognitive impairment associated with Alzheimer’s disease in mice by modulating the miR-567/NEUROD2/PSD95 axis[J]. Neuropsychiatric Disease and Treatment, 2021: 2151-2161.
[27]Sharbafshaaer M, Gigi I, Lavorgna L, et al. Repetitive Transcranial Magnetic Stimulation (rTMS) in Mild Cognitive Impairment: Effects on Cognitive Functions — A Systematic Review[J]. Journal of Clinical Medicine, 2023, 12(19): 6190.
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