Journal of Clinical Medicine Research

Objective: To analyze the distribution of wound bacteria and drug resistance in patients with traumatic infections. Methods: Clinical laboratory tests were conducted on wound secretions or pus samples from 851 suspected traumatic infection patients (sent to the orthopedic department of the hospital for examination from January 2023 to December 2024). Based on the test results, the distribution and drug resistance of bacteria in traumatic infections were analyzed. Results: (1) A total of 508 strains of non-repetitive pathogens were detected in 851 clinical samples, with a detection rate of 59.69%. Among these, 199 strains (39.17%) were Gram-positive bacteria, with Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus being the most common species; 299 strains (58.86%) were Gram-negative bacteria, mainly Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis; 10 strains (1.97%) were fungi. (2) The main antibiotic-resistant bacteria for Staphylococcus aureus and Staphylococcus epidermidis were ampicillin, with resistance rates of 96.23% and 94.11%, respectively. Both species showed high sensitivity to linezolid and vancomycin. The main resistant drugs for Escherichia coli were ampicillin and piperacillin, with resistance rates of 85.87% and 80.43%, respectively. Klebsiella pneumoniae showed no significant resistance, with the main resistant drugs being ciprofloxacin and levofloxacin, with resistance rates of 31.58% and 29.82%, respectively. Both species showed high sensitivity to imipenem, meropenem, and amikacin. Conclusion: In the clinical anti-infective treatment of orthopedic traumatic infection patients, attention should be paid to laboratory testing of pathogen types and drug resistance to ensure the safe and effective implementation of anti-infective treatment.