The Role of Brain-gut Peptides in the Symptoms of Functional Dyspepsia and Their Predictive Value for Disease
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i4.3295
Abstract
Objective: To analyze the role of brain-gut peptide in the symptoms of functional dyspepsia and its predictive effect on the disease. Methods: 100 patients with functional dyspepsia were selected from the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2022 to August 2022. The distribution of TCM syndrome of functional dyspepsia was collected, and fasting venous blood samples were collected to detect brain-intestinal peptide levels in patients with different symptoms. Moreover, patient data were collected to analyze the influencing factors of functional dyspepsia. Results: The levels of 5-hydroxytryptamine (5-HT) and motilin (MTL) in 100 functional dyspepsia patients with early satiety and upper abdominal pain were higher than those without early satiety (P<0.05), and there was no statistically significant difference between vasoactive intestinal peptide (VIP) and no early satiety (P>0.05). There was no significant difference in 5-HT, VIP and MTL levels between patients with upper abdominal distension and upper abdominal burning sensation and those without abdominal distension (P>0.05). Early satiety and upper abdominal satiety were correlated with 5-HT (P<0.05), upper abdominal distension and upper abdominal burning, early satiety, upper abdominal distension, upper abdominal pain and upper abdominal burning were not correlated with VIP (P>0.05), early satiety, upper abdominal distension and upper abdominal burning were not correlated with MTL level (P>0.05). Epigastric pain was correlated with MTL level (P<0.05). The influencing factors of 100 patients with functional dyspepsia included gender, overeating, hot food preference, picky eating, acid products, punctual eating, late night snack, daily sleep time, drug allergy history, family history, constipation and VIP level (P<0.05). Age, drinking tea, drinking alcohol, eating spicy food, eating breakfast, and eating were not included (P>0.05). Conclusion: Brain-gut peptide has predictive effect on functional dyspepsia symptoms and diseases.
Keywords
brain-intestinal peptide; Functional dyspepsia symptoms; Illness; Prediction function
Full Text
PDF - Viewed/Downloaded: 0 TimesReferences
[1] LACY BRIAN E., CHASE R. CHRISTOPHER, CANGEMI, DAVID J.. The treatment of functional dyspepsia: present and future[J]. Expert review of gastroenterology & hepatology,2023,17(1/6):9-20.
[2] CRUTCHER ROBERT, KOLASINSKI NATHAN. Functional Dyspepsia and Tricyclic Antidepressant Use in a Naval Flight Officer[J]. Aerospace medicine and human performance.,2024,95(6):337-340.
[3] YIN TAO, SUN RUIRUI, HE ZHAOXUAN, et al.Subcortical-Cortical Functional Connectivity as a Potential Biomarker for Identifying Patients with Functional Dyspepsia[J]. Cerebral cortex,2022,32(15):3347-3358.
[4] MICHAEL P. JONES, AYESHA SHAH, MARJORIE M. WALKER, et al. Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: Prevalence, temporal stability, and associated comorbidities[J]. Neurogastroenterology and motility :,2022,34(9):e14349.
[5] BARBERIO B., YIANNAKOU Y., HOUGHTON L.A., et al. Overlap of Rome IV Irritable Bowel Syndrome and Functional Dyspepsia and Effect on Natural History: A Longitudinal Follow-Up Study[J]. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association,2022,20(2):e89-e101.
[6] YUAN CHAOQUN, YONG GUIZHEN, WANG XI, et al. Developing the Patient Health Questionnaire-8 for a greater impact on the quality of life of patients with functional dyspepsia compared to Somatic Symptom Scale-8[J]. BMC Gastroenterology,2020,20(1).
[7] I‐HSUAN HUANG, JOLIEN SCHOL, GUOHAO LIN, et al. Epidemiology of functional dyspepsia and gastroparesis as diagnosed in Flemish‐Belgian primary care: A registry‐based study from the Intego database[J]. Neurogastroenterology and motility :,2024,36(5):e14778.
[8] KEE HUAT CHUAH, SUH YU CHEONG, SZE ZEE LIM, et al. Functional dyspepsia leads to more healthcare utilization in secondary care compared with other functional gastrointestinal disorders[J]. Journal of digestive diseases,2022,23(2):111-117.
[9] CHUAH KEE-HUAT, BEH KENG-HAU, RAPPEK NURUL AZMI MAHAMAD, et al. The epidemiology and quality of life of functional gastrointestinal disorders according to Rome III vs Rome IV criteria: A cross-sectional study in primary care[J]. Journal of digestive diseases,2021,22(3):159-166.
[10] DAI NING, HE QINGYUN, LIU XUEHAN, et al. Therapeutic massage/Tuina for treatment of functional dyspepsia: a systematic review and meta-analysis of randomized controlled trials[J]. Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation,2023,32(3):653-667.
[11] DE JONG, JUDITH J., LATENSTEIN, CARMEN S. S., BOERMA, DJAMILA, et al. Functional Dyspepsia and Irritable Bowel Syndrome are Highly Prevalent in Patients With Gallstones and Are Negatively Associated With Outcomes After Cholecystectomy A Prospective, Multicenter, Observational Study (PERFECT-Trial)[J]. Annals of Surgery,2022,275(6):E766-E772.
[12] WU LU, LAI YAN, WANG YING, et al. Maillard Reaction Products of Stir Fried Hordei Fructus Germinatus Are Important for Its Efficacy in Treating Functional Dyspepsia[J]. Journal of medicinal food,2020,23(4):420-431.
[13] XI‐YANG WANG, HAO WANG, YUAN‐YUAN GUAN, et al. Acupuncture for functional gastrointestinal disorders: A systematic review and meta‐analysis[J]. Journal of gastroenterology and hepatology,2021,36(11):3015-3026.
[14] LEONILDE BONFRATE, AGOSTINO DI CIAULA, PIERO PORTINCASA. Doing better with functional gastrointestinal disorders? Profiling gut microbiota and circulating antibodies to CdtB and vinculin[J]. 2022,52(1):e13702.
[15] NORWOOD, DALTON A., DOMINGUEZ, LUCIA B., PAREDES, ANDREA A., et al. Prevalence and Associated Dietary Factors of Rome IV Functional Gastrointestinal Disorders in Rural Western Honduras[J]. Digestive Diseases and Sciences,2021,66(9):3086-3095.
[16] ARAM LEE, HYO KYUNG KIM, HYUNJUNG KIM. High Prevalence and Risk Factors of Functional Gastrointestinal Disorders Among University Students in South Korea[J]. Gastroenterology Nursing,2024,47(3):195-202.
[17] Prevalence and Associated Dietary Factors of Rome IV Functional Gastrointestinal Disorders in Rural Western Honduras[J]. Digestive Diseases and Sciences,2020,66(9):3086-3095.
[18] CATHERINE P. GARDINER, PRASHANT SINGH, SARAH BALLOU, et al. Symptom severity and clinical characteristics of patients with bloating[J]. Neurogastroenterology and motility :,2022,34(3):e14229.
[19] HUSSAIN JAAFARI, LESLEY A. HOUGHTON, ROBERT M. WEST, et al. The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study[J]. Neurogastroenterology and motility :,2023,35(6):e14574.
[20] RUDERSTAM HANNA, OHLSSON BODIL. Self-reported IBS and gastrointestinal symptoms in the general population are associated with asthma, drug consumption and a family history of gastrointestinal diseases[J]. Scandinavian journal of gastroenterology.,2022,57(1/6):672-682.
[2] CRUTCHER ROBERT, KOLASINSKI NATHAN. Functional Dyspepsia and Tricyclic Antidepressant Use in a Naval Flight Officer[J]. Aerospace medicine and human performance.,2024,95(6):337-340.
[3] YIN TAO, SUN RUIRUI, HE ZHAOXUAN, et al.Subcortical-Cortical Functional Connectivity as a Potential Biomarker for Identifying Patients with Functional Dyspepsia[J]. Cerebral cortex,2022,32(15):3347-3358.
[4] MICHAEL P. JONES, AYESHA SHAH, MARJORIE M. WALKER, et al. Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: Prevalence, temporal stability, and associated comorbidities[J]. Neurogastroenterology and motility :,2022,34(9):e14349.
[5] BARBERIO B., YIANNAKOU Y., HOUGHTON L.A., et al. Overlap of Rome IV Irritable Bowel Syndrome and Functional Dyspepsia and Effect on Natural History: A Longitudinal Follow-Up Study[J]. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association,2022,20(2):e89-e101.
[6] YUAN CHAOQUN, YONG GUIZHEN, WANG XI, et al. Developing the Patient Health Questionnaire-8 for a greater impact on the quality of life of patients with functional dyspepsia compared to Somatic Symptom Scale-8[J]. BMC Gastroenterology,2020,20(1).
[7] I‐HSUAN HUANG, JOLIEN SCHOL, GUOHAO LIN, et al. Epidemiology of functional dyspepsia and gastroparesis as diagnosed in Flemish‐Belgian primary care: A registry‐based study from the Intego database[J]. Neurogastroenterology and motility :,2024,36(5):e14778.
[8] KEE HUAT CHUAH, SUH YU CHEONG, SZE ZEE LIM, et al. Functional dyspepsia leads to more healthcare utilization in secondary care compared with other functional gastrointestinal disorders[J]. Journal of digestive diseases,2022,23(2):111-117.
[9] CHUAH KEE-HUAT, BEH KENG-HAU, RAPPEK NURUL AZMI MAHAMAD, et al. The epidemiology and quality of life of functional gastrointestinal disorders according to Rome III vs Rome IV criteria: A cross-sectional study in primary care[J]. Journal of digestive diseases,2021,22(3):159-166.
[10] DAI NING, HE QINGYUN, LIU XUEHAN, et al. Therapeutic massage/Tuina for treatment of functional dyspepsia: a systematic review and meta-analysis of randomized controlled trials[J]. Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation,2023,32(3):653-667.
[11] DE JONG, JUDITH J., LATENSTEIN, CARMEN S. S., BOERMA, DJAMILA, et al. Functional Dyspepsia and Irritable Bowel Syndrome are Highly Prevalent in Patients With Gallstones and Are Negatively Associated With Outcomes After Cholecystectomy A Prospective, Multicenter, Observational Study (PERFECT-Trial)[J]. Annals of Surgery,2022,275(6):E766-E772.
[12] WU LU, LAI YAN, WANG YING, et al. Maillard Reaction Products of Stir Fried Hordei Fructus Germinatus Are Important for Its Efficacy in Treating Functional Dyspepsia[J]. Journal of medicinal food,2020,23(4):420-431.
[13] XI‐YANG WANG, HAO WANG, YUAN‐YUAN GUAN, et al. Acupuncture for functional gastrointestinal disorders: A systematic review and meta‐analysis[J]. Journal of gastroenterology and hepatology,2021,36(11):3015-3026.
[14] LEONILDE BONFRATE, AGOSTINO DI CIAULA, PIERO PORTINCASA. Doing better with functional gastrointestinal disorders? Profiling gut microbiota and circulating antibodies to CdtB and vinculin[J]. 2022,52(1):e13702.
[15] NORWOOD, DALTON A., DOMINGUEZ, LUCIA B., PAREDES, ANDREA A., et al. Prevalence and Associated Dietary Factors of Rome IV Functional Gastrointestinal Disorders in Rural Western Honduras[J]. Digestive Diseases and Sciences,2021,66(9):3086-3095.
[16] ARAM LEE, HYO KYUNG KIM, HYUNJUNG KIM. High Prevalence and Risk Factors of Functional Gastrointestinal Disorders Among University Students in South Korea[J]. Gastroenterology Nursing,2024,47(3):195-202.
[17] Prevalence and Associated Dietary Factors of Rome IV Functional Gastrointestinal Disorders in Rural Western Honduras[J]. Digestive Diseases and Sciences,2020,66(9):3086-3095.
[18] CATHERINE P. GARDINER, PRASHANT SINGH, SARAH BALLOU, et al. Symptom severity and clinical characteristics of patients with bloating[J]. Neurogastroenterology and motility :,2022,34(3):e14229.
[19] HUSSAIN JAAFARI, LESLEY A. HOUGHTON, ROBERT M. WEST, et al. The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study[J]. Neurogastroenterology and motility :,2023,35(6):e14574.
[20] RUDERSTAM HANNA, OHLSSON BODIL. Self-reported IBS and gastrointestinal symptoms in the general population are associated with asthma, drug consumption and a family history of gastrointestinal diseases[J]. Scandinavian journal of gastroenterology.,2022,57(1/6):672-682.
Copyright © 2025 Song Guo, Xiaowei Chi, Defei Yin
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
