Effect of Low Load Vibration on the Morphology and Structure of Osteoblast Cytoskeleton
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i3.2793
Abstract
Mechanical vibration is a common physical phenomenon, and mechanical vibration therapy has a long history and is currently widely used in the treatment of clinical diseases. In recent years, research on promoting fracture healing and preventing osteoporosis through vibration has been continuously deepened. From cell experiments to animal experiments and human experiments, it has been fully confirmed that low load vibration can promote bone formation, inhibit bone resorption, and have significant osteogenic effects. Low load vibration (LLV) has become a promising non-invasive treatment method in the fields of bone biology and regenerative medicine. But little is known about the cellular biology underlying this physiological phenomenon. For instance, the morphology of cells is crucial for cellular function, but there is no comprehensive description of how these morphological features are affected by vibration, what signals the cytoskeleton transmits inward after low load vibration, and what molecular effects it causes. This review aims to summarize the existing research on the effects of low load vibration on the morphology and structure of osteoblast cytoskeleton, as well as the intracellular signal transduction caused by it. It is expected to establish the connection between cell morphology and molecular mechanisms in low load vibration treatment of osteoblasts experiments.
Keywords
low load vibration; osteoblast; cytoskeleton
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[14] Maniotis AJ, Chen CS, Ingber DE. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Natl Acad Sci U S A. 1997. 94(3): 849-54.
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[27] Schmidt C, Pommerenke H, Dürr F, Nebe B, Rychly J. Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins. J Biol Chem. 1998. 273(9): 5081-5.
[28] Gould NR, Torre OM, Leser JM, Stains JP. The cytoskeleton and connected elements in bone cell mechano-transduction. Bone. 2021. 149: 115971.
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