Nanomedicine in Traditional Chinese Medicine: Research Progress and Therapeutic Mechanisms for Diabetic Pressure Ulcer Healing
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i3.2792
Abstract
Diabetes mellitus (DM) is a global health burden characterized by chronic hyperglycemia, leading to various complications including diabetic pressure ulcers (DPUs). These ulcers are notoriously difficult to heal due to factors such as impaired wound healing, oxidative stress, infection, and neuropathy. In recent years, nanotechnology has emerged as a promising tool in enhancing drug delivery and treatment efficacy for various diseases, including DPUs. This comprehensive review aims to summarize the recent advancements in nanomedicine applied to traditional Chinese medicine (TCM) and explore its therapeutic mechanisms in accelerating diabetic pressure ulcer healing.
Keywords
DPUs, Nano-TCM, nanotechnology, TCM, DM
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[2] KOTHARI V, CARDONA Z, EISENBERG Y. Adipsic diabetes insipidus [J]. Handb Clin Neurol, 2021, 181: 261-73.
[3] WANG C, HU T, LU J, et al. Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents [J]. J Med Chem, 2022, 65(15): 10626-37.
[4] CHOW A K, BHATT R, CAO D, et al. A Case Series of Delayed Proximal Ureteral Strictures After Nephron-Sparing Treatment of Renal Masses [J]. J Endourol Case Rep, 2020, 6(4): 544-7.
[5] PENG T, CHEN Y, HU W, et al. Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects [J]. Engineering, 2023, 30: 170-89.
[6] BALSA I M, CULP W T. Wound Care [J]. Vet Clin North Am Small Anim Pract, 2015, 45(5): 1049-65.
[7] KAR A, AHAMAD N, DEWANI M, et al. Wearable and implantable devices for drug delivery: Applications and challenges [J]. Biomaterials, 2022, 283: 121435.
[8] RZHEVSKIY A S, SINGH T R R, DONNELLY R F, et al. Microneedles as the technique of drug delivery enhancement in diverse organs and tissues [J]. Journal of Controlled Release, 2018, 270: 184-202.
[9] ZHU S, CHEN R, LIANG J. Progress in experimental research of Astragalus polysaccharide [J]. J Guiyang Coll Tradit Chin Med (Chin), 2018, 40: 63-6.
[10] LIU X, GUO C, YANG W, et al. Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS/NF-κB pathway to regulate macrophage polarization [J]. Carbohydr Polym, 2024, 345: 122574.
[11] HUI-YING L I, XIAO-LI Z, LI W, et al. Effects of nobiletin on high glucose-induced inflammatory cytokines and oxidative stress in rat mesangial cells [J].
[12] QIAO L, HAN M, GAO S, et al. Research progress on nanotechnology for delivery of active ingredients from traditional Chinese medicines [J]. Journal of Materials Chemistry B, 2020, 8(30): 6333-51.
[13] BAYDA S, ADEEL M, TUCCINARDI T, et al. The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine [J]. Molecules, 2019, 25(1).
[14] XIANGLIANG Y, HUIBI X, JIZHOU W, et al. Application of nano-technology in the research of traditional chinese medicine [J]. Journal-Huazhong University of Science and Technology Chinese Edition, 2000, 28(12): 104-5.
[15] FAROKHZAD O C, LANGER R. Impact of nanotechnology on drug delivery [J]. ACS Nano, 2009, 3(1): 16-20.
[16] CHEN T, REN L, LIU X, et al. DNA Nanotechnology for Cancer Diagnosis and Therapy [J]. Int J Mol Sci, 2018, 19(6).
[17] DAYYA D, O'NEILL O J, HUEDO-MEDINA T B, et al. Debridement of Diabetic Foot Ulcers [J]. Adv Wound Care (New Rochelle), 2022, 11(12): 666-86.
[18] SCHAPER N C, VAN NETTEN J J, APELQVIST J, et al. Practical Guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update) [J]. Diabetes Metab Res Rev, 2020, 36 Suppl 1: e3266.
[19] SUMPIO B E. Foot ulcers [J]. N Engl J Med, 2000, 343(11): 787-93.
[20] PANDA S, KAR A. Apigenin (4',5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice [J]. J Pharm Pharmacol, 2007, 59(11): 1543-8.
[21] JUNG U J, CHO Y Y, CHOI M S. Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice [J]. Nutrients, 2016, 8(5).
[22] KIM M A, KANG K, LEE H J, et al. Apigenin isolated from Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion [J]. Life Sci, 2014, 101(1-2): 64-72.
[23] SUH K S, OH S, WOO J T, et al. Apigenin attenuates 2-deoxy-D-ribose-induced oxidative cell damage in HIT-T15 pancreatic β-cells [J]. Biol Pharm Bull, 2012, 35(1): 121-6.
[24] ZHANG X, WANG G, GURLEY E C, et al. Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages [J]. PLoS One, 2014, 9(9): e107072.
[25] LIU K, LIU L, GUO H, et al. Redox Modulatory Cu(II)-Baicalein Microflowers Prepared in One Step Effectively Promote Therapeutic Angiogenesis in Diabetic Mice [J]. Adv Healthc Mater, 2023, 12(5): e2202010.
[26] SHIN Y, HU Y, PARK S, et al. Novel succinoglycan dialdehyde/aminoethylcarbamoyl-β-cyclodextrin hydrogels for pH-responsive delivery of hydrophobic drugs [J]. Carbohydr Polym, 2023, 305: 120568.
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[28] WANG J, WANG Y, HUANG R, et al. Uncovering the pharmacological mechanisms of Zizhu ointment against diabetic ulcer by integrating network analysis and experimental evaluation in vivo and in vitro [J]. Front Pharmacol, 2022, 13: 1027677.
[29] YAN G, WANG Y, HAN X, et al. A Modern Technology Applied in Traditional Chinese Medicine: Progress and Future of the Nanotechnology in TCM [J]. Dose Response, 2019, 17(3): 1559325819872854.
[30] SHANSHAN S U N, HUIYUN W, TINGTING C, et al. Study on Preparation and Sustained Release Behavior of the OFLO/MMT Nanocomposite [J]. Chinese Journal of Modern Applied Pharmacy, 2016, 33(10): 1283-8.
[31] GAO C, ZHOU Y, CHEN Z, et al. Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis [J]. Theranostics, 2022, 12(12): 5596-614.
[32] LIU Z, HE Z, AI X, et al. Cardamonin-loaded liposomal formulation for improving percutaneous penetration and follicular delivery for androgenetic alopecia [J]. Drug Deliv Transl Res, 2024, 14(9): 2444-60.
[33] ZHAO X, SHI A, MA Q, et al. Nanoparticles prepared from pterostilbene reduce blood glucose and improve diabetes complications [J]. J Nanobiotechnology, 2021, 19(1): 191.
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