A Glucosylceramide from Golden Mushroom: Clinical Trials and Efficacy Evaluation for Improving Human Skin Conditions
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i3.2790
Abstract
The human skin serves as a vital barrier, protecting the body from environmental factors such as pathogens, chemicals, and ultraviolet (UV) radiation. Recent research has also revealed the skin’s interaction with the brain and endocrine systems. This study focuses on the clinical efficacy of Glumole-H® Glucosylceramide Golden Mushroom, a dietary supplement formulated to improve skin hydration and inflammation. In a double-blind, placebo-controlled clinical trial involving 28 healthy participants, the effects of Glumole-H® on skin conditions were evaluated over a six-week period. Participants were divided into two groups: one group received 40 mg/day of Glumole-H®, and the other received a placebo. Key skin parameters, including trans-epidermal water loss (TEWL) and skin surface conductance, were measured at baseline, the third week, and the sixth week. Results indicated that the Glumole-H® group exhibited a significant improvement in skin hydration, with TEWL values decreasing by 15% compared to baseline and by 18% relative to the placebo group. Additionally, skin surface conductance increased by 45% compared to the placebo group. Inflammation markers also showed noticeable improvements in certain participants, with reductions in redness, scaling, and irritation. These findings suggest that Glumole-H® Glucosylceramide Golden Mushroom may enhance skin hydration, support barrier function, and mitigate inflammation, contributing to healthier skin. Further studies are recommended to explore its long-term effects and mechanisms of action in skin health improvement.
Keywords
Glucosylceramide Golden Mushroom, skin hydration, TEWL, skin inflammation, clinical trial, skin barrier function, nutritional supplement, cosmeceuticals, epidermal conductance
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