Advances in Targeted Nanomedicines in Glioma Therapy
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i3.2781
Abstract
Objective. This article explores the classification, characteristics, and challenges in the treatment of gliomas, and assesses the use of targeted nanomedicines in therapy and their research progress. Methods. A literature review was conducted to compare and analyse conventional treatments with nanomedicine delivery systems, focusing on the use of polymer-based, biomimetic, and inorganic nanoparticles in the treatment of gliomas. Results. Nanotargeted drugs significantly enhance drug bioavailability, duration of action, and reduce side effects compared to conventional formulations. Polymeric nanoparticles increase the concentration of tumour drugs through a targeting mechanism. Biomimetic nanoparticles enhance drug biocompatibility and targeting. Inorganic-type nanoparticles, on the other hand, exploit their physicochemical properties and show their potential in tumour imaging and therapy. Conclusion. Targeted nanomedicines have great potential in glioma therapy, but challenges such as target specificity, penetration efficiency and BBB damage need to be overcome. Future studies should focus on personalised therapeutic strategies to improve treatment efficacy and safety.
Keywords
glioma; targeted nanomedicines; therapy; research progress
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[11] Gao Qi. Macrophage membrane camouflaged chitosan nanogels for magnetic resonance imaging of in situ gliomas[D]. Shanghai:Donghua University,2023.
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