Efficacy and Safety of Tianma Gouteng Decoction in the Treatment of Intracerebral Hemorrhage: A Systematic Review of Randomized Controlled Trials
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i3.2771
Abstract
Objective: To systematically evaluate the efficacy and safety of Tianma Gouteng Decoction (TMGTY) in the treatment of intracerebral hemorrhage (ICH). Methods: Eight databases, including CNKI, Wanfang, VIP, China Biomedical, PubMed, Cochrane, EMBASE, and Web of Science, were searched up to February 25, 2023. Two investigators independently screened articles, extracted data, evaluated quality, and performed a systematic review or meta-analysis. Results: 11 randomized controlled trials with 977 patients were included. Compared with conventional treatment alone, the combination of TMGTY with conventional treatment improved NIHSS scores (MD=-3.86, 95% CI: -6.42, -1.31, P=0.003), treatment efficiency (RR=1.19, 95% CI: 1.13, 1.26, P<0.00001), and Barthel Index scores (MD=11.48, 95% CI: 9.71, 13.24, P<0.00001), while reducing complication rates (RR=0.24, 95% CI: 0.13, 0.45, P<0.00001), IL-6 (MD=-11.20, 95% CI: -13.84, -8.57, P<0.00001), and TNF-α levels (MD=-13.88, 95% CI: -16.73, -11.02, P<0.00001). Conclusion: Current clinical evidence suggests that TMGTY combined with conventional treatment is safe and effective in the treatment of ICH, more high-quality randomized controlled clinical trials are needed to validate and support the findings.
Keywords
traditional Chinese medicine, Tianma Gouteng Decoction, intracerebral hemorrhage
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[3]Pinho J, Costa AS, Araújo JM, Amorim JM, Ferreira C. 2019. Intracerebral hemorrhage outcome: A comprehensive update. J Neurol Sci. 398: 54-66.
[4]Garg R, Biller J. 2019. Recent advances in spontaneous intracerebral hemorrhage. F1000Res. 8.
[5] Duan T, Li L, Yu Y, et al. 2022. Traditional Chinese medicine use in the pathophysiological processes of intracerebral hemorrhage and comparison with conventional therapy. Pharmacol Res. 179: 106200.
[6]Chen B, Wang Y, He Z, Wang D, Yan X, Xie P. 2018. Tianma Gouteng decoction for essential hypertension: Protocol for a systematic review and meta-analysis. Medicine (Baltimore). 97(8): e9972.
[7]Chik SC, Or TC, Luo D, Yang CL, Lau AS. 2013. Pharmacological effects of active compounds on neurodegenerative disease with gastrodia and uncaria decoction, a commonly used poststroke decoction. ScientificWorldJournal. 2013: 896873.
[8] Page MJ, McKenzie JE, Bossuyt PM, et al. 2022. [The PRISMA 2020 statement: an updated guideline for reporting systematic reviewsDeclaración PRISMA 2020: una guía actualizada para la publicación de revisiones sistemáticas]. Rev Panam Salud Publica. 46: e112.
[9]Dong JP. 2013. Clinical observation on the treatment of acute cerebral hemorrhage with Tianma Gouteng Decoction. Chinese Journal of Modern Drug Application. 7(24): 154.
[10]Wang HF, Li Q, Zhao J,et al. 2021a. Evaluation of the clinical effect of combined Chinese and Western medicine treatment in patients with hypertensive cerebral hemorrhage and its effect on patients' quality of life. Diet Health. (35): 138-139.
[11]Li Q, Zhao J, Wang HF, et al. 2020. The efficacy of combined minimally invasive tube drainage with Tianma Gouteng Decoction in patients with hypertensive cerebral hemorrhage and the effect on patients' quality of life. Electronic Journal of Practical Gynecological Endocrinology. 7(34): 148+150.
[12]Li Q, Zhao J, Wang HF, et al. 2020. The efficacy of combined minimally invasive tube drainage with Tianma Gouteng Decoction in patients with hypertensive cerebral hemorrhage and the effect on patients' quality of life. Electronic Journal of Practical Gynecological Endocrinology. 7(34): 148+150.
[13]Li Q, Zhao J, Wang HF, et al. 2020. The efficacy of combined minimally invasive tube drainage with Tianma Gouteng Decoction in patients with hypertensive cerebral hemorrhage and the effect on patients' quality of life. Electronic Journal of Practical Gynecological Endocrinology. 7(34): 148+150.
[14]Li Y, Guo MY, Zhang JX. 2020. Exploring the efficacy analysis of Tianma Gouteng Decoction plus reduction combined with rehabilitation physiotherapy in the treatment of hypertensive cerebral hemorrhage. Prevention and Treatment of Cardiovascular Disease. 10(24): 18-20.
[15]Li Q, Zhao J, Wang HF, et al. 2020. The efficacy of combined minimally invasive tube drainage with Tianma Gouteng Decoction in patients with hypertensive cerebral hemorrhage and the effect on patients' quality of life. Electronic Journal of Practical Gynecological Endocrinology. 7(34): 148+150.
[16]Wang HF, Li Q, Zhao J,et al. 2021a. Evaluation of the clinical effect of combined Chinese and Western medicine treatment in patients with hypertensive cerebral hemorrhage and its effect on patients' quality of life. Diet Health. (35): 138-139.
[17]Zhang CJ, Meng XK, Yu XP. 2021. Clinical study of modified Tianma-Gouteng Decoction combined with conventional western medicine in the treatment of cerebral hemorrhage with syndrome of hyperactive liver yang causing wind. International Journal of Traditional Chinese Medicine. 43(5): 446-451.
[18]An SJ, Kim TJ, Yoon BW. 2017. Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update. J Stroke. 19(1): 3-10.
[19]]Ren H, Han R, Chen X, et al. 2020. Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update. J Cereb Blood Flow Metab. 40(9): 1752-1768.Pinho J, Costa AS, Araújo JM, Amorim JM, Ferreira C. 2019. Intracerebral hemorrhage outcome: A comprehensive update. J Neurol Sci. 398: 54-66.
[20]Duan X, Wen Z, Shen H, Shen M, Chen G. 2016. Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy. Oxid Med Cell Longev. 2016: 1203285.
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