Journal of Clinical Medicine Research

To explore the potential and challenges of tumour stem cells in the treatment of digestive tract tumours, the article analyses the key role of tumour stem cells in tumourigenesis and treatment resistance using a systematic review as an approach. Tumour stem cells are capable of self-renewal and multidirectional differentiation, which have a significant impact on long-term tumour survival and recurrence. Therapeutic strategies for targeting tumour stem cells include labelling and isolation techniques as well as the development of targeted drugs aimed at improving therapeutic efficacy and prolonging patient survival. However, therapeutic resistance caused by tumour stem cells remains one of the challenges and requires further in-depth studies and effective therapeutic strategies, providing theoretical support for future clinical studies and the development of individualized treatment protocols.