Effects of Intrathecal Versus General Anesthesia on Postoperative Cognitive Function in Elderly Hip Fracture Patients: a System Review and Meta Analysis Protocol
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i2.2322
Abstract
Randomized controlled studies have shown that the incidence of postoperative cognitive function in elderly patients undergoing hip fracture surgery varies significantly by anesthesia type. The aim of this study was to assess the effects of intrathecal anesthesia and general anesthesia on postoperative cognitive function in elderly hip fracture by system review and meta-analysis. This study followed the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-analyses. First, the Cochrane Library, Web of Science, PubMed, EMBASE, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Database, and Clinical Trials Database were searched. Second, the literature was screened and identified for inclusion step by step according to the established inclusion and exclusion criteria using Endnote. Further, Excel 2010 was used to record the basic characteristics and relevant data of the included literature, and the Cochrane Risk of Bias Assessment Tool was used to rate the quality of each included study. Subsequently, meta-analysis was performed using RevMan 5.3 software to assess the effects of intrathecal anesthesia and general anesthesia on postoperative cognitive function of hip fracture in the elderly, and funnel plots were drawn to assess publication bias. The results of this systematic evaluation and meta-analysis will be published in a peer-reviewed journal.
Keywords
intrathecal anesthesia; general anesthesia; hip fracture; cognitive function; systematic evaluation; meta-analysis; protocol
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[2]DI Monaco M, Sgarbanti M, Trombetta S, et al. Cognitive assessment to optimize prediction of functional outcome in subacute hip fracture: a short-term prospective study[J]. European Journal of Physical and Rehabilitation Medicine, 2024, 60(2): 340-348.
[3]National Hip Fracture Database. Available from: https://www.nhfd.co.uk/
[4]Cheung C-L, Ang S B, Chadha M, et al. An updated hip fracture projection in Asia: the Asian Federation of Osteoporosis Societies study[J]. Osteoporosis and Sarcopenia, 2018, 4(1): 16-21.
[5]Noritake H, Takegami Y, Tokutake K, et al. Descriptive analysis of incidence and risk factors for short intramedullary nail breakage in femoral intertrochanteric fractures: a multicenter (TRON group) retrospective study[J]. European Journal of Orthopaedic Surgery & Traumatology: Orthopedie Traumatologie, 2024.
[6]Bhushan S, Huang X, Duan Y, et al. The impact of regional versus general anesthesia on postoperative neurocognitive outcomes in elderly patients undergoing hip fracture surgery: a systematic review and meta-analysis[J]. International Journal of Surgery, 2022, 105: 106854.
[7]White S M, Moppett I K, Griffiths R. Outcome by mode of anaesthesia for hip fracture surgery. an observational audit of 65 535 patients in a national dataset [J]. Anaesthesia, 2014, 69(3): 224-230.
[8]Ahn E J, Kim H J, Kim K W, et al. Comparison of general anaesthesia and regional anaesthesia in terms of mortality and complications in elderly patients with hip fracture: a nationwide population-based study[J]. BMJ open, 2019, 9(9): e029245.
[9]Li T, Li J, Yuan L, et al. Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial[J]. JAMA, 2022, 327(1): 50-58.
[10]Page M J, McKenzie J E, Bossuyt P M, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews[J]. BMJ (Clinical research ed.), 2021, 372: n71.
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