Clinical Evaluation of Xpert Xpress SARS-CoV-2/Flu/RSV Combination Test in China
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i2.2314
Abstract
During influenza season, the influenza virus and respiratory syncytial virus (RSV) can cause severe respiratory infections. The clinical manifestation of symptoms caused by COVID-19, influenza virus and RSV are very similar.We conducted the performance characteristics of the Xpert Xpress SARS-CoV-2/Flu/RSV combined assay in China and came up with the detection results of the two detection methods are almost the same for all targets, and the consistency rate is close to 100%.This indicates that the assay is of great clinical value for distinguishing infections caused by these four viruses.
Keywords
gGene; Xpert; SARS-CoV-2; influenza; RSV; detection
Funding
Ethics Committee of the Weifang Second People's Hospital (ky2022-002-01); Weifang Health Commission's research project (WFWSJK-2022-071); WeiFang Science and Technology Project (2023YX075)
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[1] Jones KE, Patel NG, Levy MA, et al. Global trends in emerging infectious diseases. Nature. 2008;451(7181):990-993.
[2] Morens DM, Folkers GK, Fauci AS. The challenge of emerging and re-emerging infectious diseases [published correction appears in Nature. 2010 Jan 7;463(7277):122]. Nature. 2004;430(6996):242-249.
[3] Bogoch II, Watts A, Thomas-Bachli A, et al. Potential for global spread of a novel coronavirus from China. J Travel Med. 2020;27(2):taaa011. doi:10.1093/jtm/taaa011
[4] Sohrabi C, Alsafi Z, O'Neill N, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020;76:71-76.
[5] Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020 Mar 19;91(1):157-160. doi: 10.23750/abm.v91i1.9397. PMID: 32191675; PMCID: PMC7569573.
[6] Bloom-Feshbach K, Alonso WJ, Charu V, et al. Latitudinal variations in seasonal activity of influenza and respiratory syncytial virus (RSV): a global comparative review. PLoS One. 2013;8(2):e54445. doi: 10.1371/journal.pone.0054445. Epub 2013 Feb 14. PMID: 23457451; PMCID: PMC3573019.
[7] Timothy M Uyeki, Henry H Bernstein, John S Bradley, et al.Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza, Clinical Infectious Diseases, Volume 68, Issue 6, 15 March 2019, Pages e1-e47, https://doi.org/10.1093/cid/ciy866
[8] Mostafa HH, Carroll KC, Hicken R, et al. Multicenter Evaluation of the Cepheid Xpert Xpress SARS-CoV-2/Flu/RSV Test. J Clin Microbiol. 2021 Feb 18;59(3):e02955-20. doi: 10.1128/JCM.02955-20. PMID: 33298613; PMCID: PMC8106732.
[2] Morens DM, Folkers GK, Fauci AS. The challenge of emerging and re-emerging infectious diseases [published correction appears in Nature. 2010 Jan 7;463(7277):122]. Nature. 2004;430(6996):242-249.
[3] Bogoch II, Watts A, Thomas-Bachli A, et al. Potential for global spread of a novel coronavirus from China. J Travel Med. 2020;27(2):taaa011. doi:10.1093/jtm/taaa011
[4] Sohrabi C, Alsafi Z, O'Neill N, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020;76:71-76.
[5] Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020 Mar 19;91(1):157-160. doi: 10.23750/abm.v91i1.9397. PMID: 32191675; PMCID: PMC7569573.
[6] Bloom-Feshbach K, Alonso WJ, Charu V, et al. Latitudinal variations in seasonal activity of influenza and respiratory syncytial virus (RSV): a global comparative review. PLoS One. 2013;8(2):e54445. doi: 10.1371/journal.pone.0054445. Epub 2013 Feb 14. PMID: 23457451; PMCID: PMC3573019.
[7] Timothy M Uyeki, Henry H Bernstein, John S Bradley, et al.Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza, Clinical Infectious Diseases, Volume 68, Issue 6, 15 March 2019, Pages e1-e47, https://doi.org/10.1093/cid/ciy866
[8] Mostafa HH, Carroll KC, Hicken R, et al. Multicenter Evaluation of the Cepheid Xpert Xpress SARS-CoV-2/Flu/RSV Test. J Clin Microbiol. 2021 Feb 18;59(3):e02955-20. doi: 10.1128/JCM.02955-20. PMID: 33298613; PMCID: PMC8106732.
Copyright © 2024 Lei Chen, Zhaobao Pan, Yuanyuan Tang, Jifei Cai, Xiaoying He
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