The Hypothesis and Research on the Regulation of Mouse Feeding Behavior by Astrocytes in the Lateral Hypothalamic Area
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i2.2305
Abstract
Numerous studies have shown that the central nervous system plays a crucial role in regulating feeding behavior [1]. Within the central nervous system, many nuclei and neural circuitry are involved in regulating feeding behavior, such as the ventral tegmental area (VTA), lateral hypothalamus (LH), tuberomammillary nucleus (TN), and amygdala (CeA). Among these, the lateral hypothalamus is a critical target for the regulation of homeostatic feeding. Previous studies on LH regulation of feeding behavior have mostly focused on neurons and neural circuits, with relatively fewer studies on astrocytes.
Keywords
lateral hypothalamus, astrocytes, feeding regulation, calcium channel signaling, immunohistochemistry research
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References
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[1]Locke A, Kahali B, Berndt S, et al. Genetic studies of body mass index yield new insights for obesity biology[J], 2015, 518(7538):197-206.
[2]Alon T, Friedman J J T J O N T O J O T S F N. Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons[J], 2006, 26(2):389-97.
[3]Fujita A, Zhong L, Antony M, et al. Neurokinin B-Expressing Neurons of the Central Extended Amygdala Mediate Inhibitory Synaptic Input onto Melanin-Concentrating Hormone Neuron Subpopulations[J], 2021, 41(46):9539-9560.
[4]Nieh E, Matthews G, Allsop S, et al. Decoding neural circuits that control compulsive sucrose seeking[J], 2015, 160(3):528-41.
[5]Nieh E, Vander Weele C, Matthews G, et al. Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation[J], 2016, 90(6):1286-1298.
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