Study on the in Vitro Inhibitory Activity of Peony Seed Blended Oil on α-Amylase and α-Glucosidase
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i2.2288
Abstract
In recent years, China has been suffering from an increasing number of patients with chronic diseases such as diabetes, hypertension, and heart disease, which are gradually showing a "younger" trend. As health problems become more prominent, choosing good cooking oil has become crucial. People are beginning to realize the significance of a balanced diet and healthy eating habits in maintaining good health. Peony seed oil is rich in nutrients, and its content of unsaturated fatty acids can reach over 85%, with the highest content of α-linolenic acid, which effectively lowers blood sugar. Suppose soybean oil and rapeseed oil are combined and added. In that case, the original efficacy of peony seed oil can be complemented and enhanced, its mechanism of action network can be sound, and its nutritional composition can be enriched. We can obtain an optimal ratio for mixing the above several oils by studying their effects and roles. This paper explored the inhibitory effects of peony seed oil, soybean oil, and rapeseed oil on α-amylase activity and α-glucosidase activity, and their optimal ratios were determined by a one-way test and response surface method. The results showed that the optimal ratio was peony seed oil: soybean oil: rapeseed oil = 60:27:13. The results provide specific technology and reference for the development and utilization of peony and provide a particular theoretical basis for the development of hypoglycemic drugs or health food.
Keywords
peony seed oil, soybean oil, rapeseed oil, inhibition rate, α-glucosidase, α-amylase, hypoglycemia
Full Text
PDF - Viewed/Downloaded: 4 TimesReferences
[1] Xu Kaimeng, Ye Qian, Hu Qian, Wang Yanfeng, Wang Juan,. Comparative study on the chemical composition of two peony pods and GC/MS of cold and hot water extracts [J]. Forest Products Industry, 2021, (01): 43-47.
[2] Li Kai, Zhou Ning, Li Heyu,. Research progress on the components and functions of peony flowers and peony seeds [J]. Food Research and Development, 2012, (03): 228-230.
[3] Wang Yun. Research on the nutritional components and functional effects of peony seed oil [D]. Shandong University, 2012.
[4] Wu Jingyi. Research on the chemical composition of peony seeds[D]. Beijing University of Chinese Medicine, 2014.
[5] Wang Shunli, Ren Xiuxia, Xue Jingqi, et al. Research progress on peony seed oil's composition, efficacy, and processing technology [J]. Chinese Journal of Cereals and Oils, 2016, 31 (03): 139-146.
[6] Dong Zhenxing, Peng Daiyin, Xuan Zihua, et al. Experimental study on the blood lipid and blood sugar lowering effects of peony seed oil [J]. Anhui Medicine, 2013, 17 (08): 1286-1289.
[7] Rao Hongyan, Wang Chengzhong, Yuan Yaguang. Analysis of water-organic solvent extraction of peony seed oil and its antioxidant activity [J]. Chinese Journal of Cereals and Oils, 2015, 30 (10): 61-66.
[8] Zhang Ping. Preparation, purification, component analysis, and efficacy evaluation of peony seed oil [D]. Capital Normal University, 2009.
[9] Zhao Erlao, Zhao Sanhu, Fan Jianfeng, et al. Research progress on the inhibitory effect of active ingredients in natural products on α-amylase [J]. Food Research & Development, 2020, 41(19).
[10] Sun Heying, Fu Pingping, Wang Qiulan,. The third generation oral hypoglycemic drug acarbose [J]. Hebei Medicine, 2007, (08): 858-859.
[11] Qin Junwei. Effect of aminocyclic alcohol compounds on acarbose fermentation process [D]. Instructor: Zheng Yuguo; Xue Yaping. Zhejiang University of Technology, 2018.
[12] Long Jiefeng, Chen Wenjing, Li Jinqiao. Research on extraction technology and hypoglycemic activity of polygonatum polysaccharide [J]. Asia Pacific Traditional Medicine, 2024, 20(04): 49-53.
[13] Zhang Huanhuan, Yang Ruinan, Yan Zhenli, Zhao Zigao, Chang Chun. Ultra-low acid hydrolysis of wheat B starch slurry and its kinetics [J]. Biomass Chemical Engineering, 2024, 58(02): 22-30.
[14] Grussu, D., Stewart, D., & Mcdougall, G. J. (2011). Berry polyphenols inhibit α-amylase in vitro: identifying active components in rowanberry and raspberry. Journal of Agricultural and Food Chemistry, 59(6), 2324-2331.
[15] Wen, Z., Ling, M., Yu, S., et al. (2019). Study the inhibitory effect of ethanol extracts from different medicinal parts of Syzygium pumila on α-glucosidase and α-amylase activities. Chinese Pharmacy, 30(23), 3246-3251. DOI:10.6039/j.issn.1001-0408.2019.23.14.
[16] Cho, J., Lee, K., Park, S., et al. (2013). Isolation and identification of alpha-glucosidase inhibitors from the stem bark of the nutgall tree (Rhus javanica Linne). Journal of the Korean Society for Applied Biological Chemistry, 56(5), 547-552.
[17] Pan, Y., Liu, X., Wang, Y., et al. (2022). Study the in vitro inhibitory activity of blueberry leaf polyphenols on α-amylase and α-glucosidase. Natural Product Research and Development, (04), 579-587.
[18] Hong, H. D., Kim, J. C., Lim, T. G., et al. (2018). Mixing ratio optimization for functional complex extracts of Rhodiola crenulata, Panax quinquefolius, and Astragalus membranaceus using mixture design and verification of immune functional efficacy in animal models. Journal of Functional Foods, 40, 447-454.
[19] Wang, Q., & Yang, J. (Eds.). (2009). Fundamentals of Food Experiment Design and Statistical Analysis. Beijing: China Agricultural University Press.
[20] Su, J., Zhang, Y., Liu, C., et al. (2018). Hypoglycemic and hypolipidemic activities of peony seed oil and plant extracts. Journal of Food and Biotechnology, 37(07), 739-746.
[2] Li Kai, Zhou Ning, Li Heyu,. Research progress on the components and functions of peony flowers and peony seeds [J]. Food Research and Development, 2012, (03): 228-230.
[3] Wang Yun. Research on the nutritional components and functional effects of peony seed oil [D]. Shandong University, 2012.
[4] Wu Jingyi. Research on the chemical composition of peony seeds[D]. Beijing University of Chinese Medicine, 2014.
[5] Wang Shunli, Ren Xiuxia, Xue Jingqi, et al. Research progress on peony seed oil's composition, efficacy, and processing technology [J]. Chinese Journal of Cereals and Oils, 2016, 31 (03): 139-146.
[6] Dong Zhenxing, Peng Daiyin, Xuan Zihua, et al. Experimental study on the blood lipid and blood sugar lowering effects of peony seed oil [J]. Anhui Medicine, 2013, 17 (08): 1286-1289.
[7] Rao Hongyan, Wang Chengzhong, Yuan Yaguang. Analysis of water-organic solvent extraction of peony seed oil and its antioxidant activity [J]. Chinese Journal of Cereals and Oils, 2015, 30 (10): 61-66.
[8] Zhang Ping. Preparation, purification, component analysis, and efficacy evaluation of peony seed oil [D]. Capital Normal University, 2009.
[9] Zhao Erlao, Zhao Sanhu, Fan Jianfeng, et al. Research progress on the inhibitory effect of active ingredients in natural products on α-amylase [J]. Food Research & Development, 2020, 41(19).
[10] Sun Heying, Fu Pingping, Wang Qiulan,. The third generation oral hypoglycemic drug acarbose [J]. Hebei Medicine, 2007, (08): 858-859.
[11] Qin Junwei. Effect of aminocyclic alcohol compounds on acarbose fermentation process [D]. Instructor: Zheng Yuguo; Xue Yaping. Zhejiang University of Technology, 2018.
[12] Long Jiefeng, Chen Wenjing, Li Jinqiao. Research on extraction technology and hypoglycemic activity of polygonatum polysaccharide [J]. Asia Pacific Traditional Medicine, 2024, 20(04): 49-53.
[13] Zhang Huanhuan, Yang Ruinan, Yan Zhenli, Zhao Zigao, Chang Chun. Ultra-low acid hydrolysis of wheat B starch slurry and its kinetics [J]. Biomass Chemical Engineering, 2024, 58(02): 22-30.
[14] Grussu, D., Stewart, D., & Mcdougall, G. J. (2011). Berry polyphenols inhibit α-amylase in vitro: identifying active components in rowanberry and raspberry. Journal of Agricultural and Food Chemistry, 59(6), 2324-2331.
[15] Wen, Z., Ling, M., Yu, S., et al. (2019). Study the inhibitory effect of ethanol extracts from different medicinal parts of Syzygium pumila on α-glucosidase and α-amylase activities. Chinese Pharmacy, 30(23), 3246-3251. DOI:10.6039/j.issn.1001-0408.2019.23.14.
[16] Cho, J., Lee, K., Park, S., et al. (2013). Isolation and identification of alpha-glucosidase inhibitors from the stem bark of the nutgall tree (Rhus javanica Linne). Journal of the Korean Society for Applied Biological Chemistry, 56(5), 547-552.
[17] Pan, Y., Liu, X., Wang, Y., et al. (2022). Study the in vitro inhibitory activity of blueberry leaf polyphenols on α-amylase and α-glucosidase. Natural Product Research and Development, (04), 579-587.
[18] Hong, H. D., Kim, J. C., Lim, T. G., et al. (2018). Mixing ratio optimization for functional complex extracts of Rhodiola crenulata, Panax quinquefolius, and Astragalus membranaceus using mixture design and verification of immune functional efficacy in animal models. Journal of Functional Foods, 40, 447-454.
[19] Wang, Q., & Yang, J. (Eds.). (2009). Fundamentals of Food Experiment Design and Statistical Analysis. Beijing: China Agricultural University Press.
[20] Su, J., Zhang, Y., Liu, C., et al. (2018). Hypoglycemic and hypolipidemic activities of peony seed oil and plant extracts. Journal of Food and Biotechnology, 37(07), 739-746.
Copyright © 2024 Tiantian Sun, Zirui Chang, Fengliang Zhong, Zishu Li, Yu Fu, Yuning Gu
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License