Gastric-type Endocervical Adenocarcinoma Associated with Peutz-Jeghers Syndrome: A Case Report with Imaging Findings
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i2.2047
Abstract
Gastric-type endocervical adenocarcinoma (GAS) is the most common disease of cervical cancer that is not caused by HPV but is not taken seriously. We describe a woman diagnosed with GAS and Peutz-Jeghers syndrome (PJS) in this report. A 44-year-old woman experienced sporadic vaginal bleeding for one month. In addition, ten years ago, the patient was diagnosed with PJS. In place of the usual cervical structures, computed tomography and magnetic resonance imaging revealed an irregular cystic-solid mass, mostly composed by cystic tissue. Due to the development characteristics of gastric-type endocervical adenocarcinoma, preoperative imaging is of tremendous assistance in diagnosing patients. There is no previous case of predominantly cystic GAS with such a complete history and characteristic imaging findings. This discovery may aid future diagnoses of similar cases.
Keywords
gastric-type endocervical adenocarcinoma, human papillomavirus, peutz-jeghers syndrome, magnetic resonance imaging, computed tomography
Full Text
PDF - Viewed/Downloaded: 1 TimesReferences
[1].Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, et al. International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix. Am J Surg Pathol. 2018;42(2):214-26.
[2].Markowitz LE, Naleway AL, Lewis RM, Crane B, Querec TD, Weinmann S, et al. Declines in HPV vaccine type prevalence in women screened for cervical cancer in the United States: Evidence of direct and herd effects of vaccination. Vaccine. 2019;37(29):3918-24.
[3].Park E, Kim SW, Kim S, Kim H-S, Lee J-Y, Kim YT, et al. Genetic characteristics of gastric-type mucinous carcinoma of the uterine cervix. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. 2021;34(3):637-46.
[4].Kusanagi Y, Kojima A, Mikami Y, Kiyokawa T, Sudo T, Yamaguchi S, et al. Absence of high-risk human papillomavirus (HPV) detection in endocervical adenocarcinoma with gastric morphology and phenotype. Am J Pathol. 2010;177(5):2169-75.
[5].Kojima A, Mikami Y, Sudo T, Yamaguchi S, Kusanagi Y, Ito M, et al. Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix. Am J Surg Pathol. 2007;31(5):664-72.
[6].Talia KL, McCluggage WG. The developing spectrum of gastric-type cervical glandular lesions. Pathology. 2018;50(2):122-33.
[7].Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, et al. Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. 2011;21(7):1287-96.
[8].Park KJ, Kim MH, Kim JK, Cho KS. Gastric-Type Adenocarcinoma of the Uterine Cervix: Magnetic Resonance Imaging Features, Clinical Outcomes, and Prognostic Factors. Int J Gynecol Cancer. 2018;28(6):1203-10.
[9].Daniell J, Plazzer J-P, Perera A, Macrae F. An exploration of genotype-phenotype link between Peutz-Jeghers syndrome and STK11: a review. Fam Cancer. 2018;17(3):421-7.
[10]. Chen L, Niu Y, Wan X, Yu L, Zhang X, Strickland AL, et al. Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas. BMC Cancer. 2021;21(1):1095.
[11]. Karamurzin YS, Kiyokawa T, Parkash V, Jotwani AR, Patel P, Pike MC, et al. Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis. Am J Surg Pathol. 2015;39(11):1449-57.
[12]. Nishio S, Mikami Y, Tokunaga H, Yaegashi N, Satoh T, Saito M, et al. Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study. Gynecol Oncol. 2019;153(1):13-9.
[13]. Koh W-J, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, et al. Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2019;17(1):64-84.
[14].Turashvili G, Park KJ. Cervical Glandular Neoplasia: Classification and Staging. Surgical Pathology Clinics. 2019;12(2):281-313.
[15]. Ohya A, Kobara H, Miyamoto T, Komatsu M, Shiozawa T, Fujinaga Y. Usefulness of the 'cosmos pattern' for differentiating between cervical gastric-type mucin-positive lesions and other benign cervical cystic lesions in magnetic resonance images. J Obstet Gynaecol Res. 2021;47(2):745-56.
[2].Markowitz LE, Naleway AL, Lewis RM, Crane B, Querec TD, Weinmann S, et al. Declines in HPV vaccine type prevalence in women screened for cervical cancer in the United States: Evidence of direct and herd effects of vaccination. Vaccine. 2019;37(29):3918-24.
[3].Park E, Kim SW, Kim S, Kim H-S, Lee J-Y, Kim YT, et al. Genetic characteristics of gastric-type mucinous carcinoma of the uterine cervix. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. 2021;34(3):637-46.
[4].Kusanagi Y, Kojima A, Mikami Y, Kiyokawa T, Sudo T, Yamaguchi S, et al. Absence of high-risk human papillomavirus (HPV) detection in endocervical adenocarcinoma with gastric morphology and phenotype. Am J Pathol. 2010;177(5):2169-75.
[5].Kojima A, Mikami Y, Sudo T, Yamaguchi S, Kusanagi Y, Ito M, et al. Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix. Am J Surg Pathol. 2007;31(5):664-72.
[6].Talia KL, McCluggage WG. The developing spectrum of gastric-type cervical glandular lesions. Pathology. 2018;50(2):122-33.
[7].Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, et al. Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. 2011;21(7):1287-96.
[8].Park KJ, Kim MH, Kim JK, Cho KS. Gastric-Type Adenocarcinoma of the Uterine Cervix: Magnetic Resonance Imaging Features, Clinical Outcomes, and Prognostic Factors. Int J Gynecol Cancer. 2018;28(6):1203-10.
[9].Daniell J, Plazzer J-P, Perera A, Macrae F. An exploration of genotype-phenotype link between Peutz-Jeghers syndrome and STK11: a review. Fam Cancer. 2018;17(3):421-7.
[10]. Chen L, Niu Y, Wan X, Yu L, Zhang X, Strickland AL, et al. Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas. BMC Cancer. 2021;21(1):1095.
[11]. Karamurzin YS, Kiyokawa T, Parkash V, Jotwani AR, Patel P, Pike MC, et al. Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis. Am J Surg Pathol. 2015;39(11):1449-57.
[12]. Nishio S, Mikami Y, Tokunaga H, Yaegashi N, Satoh T, Saito M, et al. Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study. Gynecol Oncol. 2019;153(1):13-9.
[13]. Koh W-J, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, et al. Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2019;17(1):64-84.
[14].Turashvili G, Park KJ. Cervical Glandular Neoplasia: Classification and Staging. Surgical Pathology Clinics. 2019;12(2):281-313.
[15]. Ohya A, Kobara H, Miyamoto T, Komatsu M, Shiozawa T, Fujinaga Y. Usefulness of the 'cosmos pattern' for differentiating between cervical gastric-type mucin-positive lesions and other benign cervical cystic lesions in magnetic resonance images. J Obstet Gynaecol Res. 2021;47(2):745-56.
Copyright © 2024 Qingwen Xiao, Kuiming Jiang
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License