Advances in Peripheral Blood Parameter Ratios in IBD
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i2.2000
Abstract
In recent years, studies have found that the ratio of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, lymphocyte to monocyte ratio, CRP to albumin ratio, and other comprehensive indicators derived from peripheral blood parameters are valuable for the evaluation and differential diagnosis of disease activity. This article provides an overview of the use of ratios of several peripheral blood parameters in the diagnosis of inflammatory bowel disease activity.
Keywords
biomarkers, ulcerative colitis, Crohn's disease, inflammatory bowel disease, CRP/ALB
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[3] Buie MJ, Quan J, Windsor JW, et al. Global Hospitalization Trends for Crohn’s Disease and Ulcerative Colitis in the 21st Century: A Systematic Review With Temporal Analyses[J]. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, 2023, 21(9): 2211-2221.
[4] Ramos GP, Papadakis KA. Mechanisms of Disease: Inflammatory Bowel Diseases[J]. Mayo Clinic Proceedings, 2019, 94(1): 155-165.
[5] Agrawal M, Spencer EA, Colombel JF, et al. Approach to the Management of Recently Diagnosed Inflammatory Bowel Disease Patients: A User’s Guide for Adult and Pediatric Gastroenterologists[J]. Gastroenterology, 2021, 161(1): 47-65.
[6] Buisson A, Gonzalez F, Poullenot F, et al. Comparative Acceptability and Perceived Clinical Utility of Monitoring Tools: A Nationwide Survey of Patients with Inflammatory Bowel Disease[J]. Inflammatory Bowel Diseases, 2017, 23(8): 1425-1433.
[7] Henriksen M, Jahnsen J, Lygren I, et al. C-reactive protein: a predictive factor and marker of inflammation in inflammatory bowel disease. Results from a prospective population-based study[J]. Gut, 2008, 57(11): 1518-1523.
[8] Chen YH, Wang L, Feng SY, et al. The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease[J]. Gastroenterology Research and Practice, 2020, 2020: 3467419.
[9] Zhou FS, Gao N, Sun X, et al. C-reactive protein/abumin ratio is a useful biomarker for predicting the mucosal healing in the Crohn disease: A retrospective study[J]. Medicine, 2021, 100(10): e24925.
[10] Glapa-Nowak A, Szczepanik M, Banaszkiewicz A, et al. C-Reactive Protein/Albumin Ratio at Diagnosis of Pediatric Inflammatory Bowel Disease: A Retrospective Multi-Center Study[J]. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 2022, 28: e937842.
[11] Pan J, Li J, Gao Y. The value of 7 peripheral blood serum ratios in diagnosis and prediction of disease activity of patients within inflammatory bowel disease individuals[J]. Frontiers in Medicine, 2023, 10: 1122005.
[12] Jeong Y, Jeon SR, Kim HG, et al. The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis[J]. Intestinal Research, 2021, 19(1): 62-70.
[13] Templeton AJ, McNamara MG, Sheruga B, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis[J]. Journal of the National Cancer Institute, 2014, 106(6): dju124.
[14] Phillipson M, Kubes P. The Healing Power of Neutrophils[J]. Trends in Immunology, 2019, 40(7): 635-647.
[15] Acarturk G, Acay A, Demir K, et al. Neutrophil-to-lymphocyte ratio in inflammatory bowel disease - as a new predictor of disease severity[J]. Bratislavske Lekarske Listy, 2015, 116(4): 213-217.
[16] P SHO, H HG, Ym E, et al. Neutrophil-to-Lymphocyte Ratio: An Easy Marker for the Diagnosis and Monitoring of Inflammatory Bowel Disease in Children[J]. Digestive diseases and sciences, 2023, 68(1).
[17] Gao SQ, Huang LD, Dai RJ, et al. Neutrophil-lymphocyte ratio: a controversial marker in predicting Crohn’s disease severity[J]. International Journal of Clinical and Experimental Pathology, 2015, 8(11): 14779-14785.
[18] Nishida Y, Hosomi S, Yamagami H, et al. Neutrophil-to-Lymphocyte Ratio for Predicting Loss of Response to Infliximab in Ulcerative Colitis[J]. PloS One, 2017, 12(1): e0169845.
[19] Voudoukis E, Karmiris K, Koutroubakis IE. Multipotent role of platelets in inflammatory bowel diseases: a clinical approach[J]. World Journal of Gastroenterology, 2014, 20(12): 3180-3190.
[20] Bertani L, Rossari F, Barberio B, et al. Novel Prognostic Biomarkers of Mucosal Healing in Ulcerative Colitis Patients Treated With Anti-TNF: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio[J]. Inflammatory Bowel Diseases, 2020, 26(10): 1579-1587.
[21] Dentali F, Nigro O, Squizzato A, et al. Impact of neutrophils to lymphocytes ratio on major clinical outcomes in patients with acute coronary syndromes: A systematic review and meta-analysis of the literature[J]. International Journal of Cardiology, 2018, 266: 31-37.
[22] Grainger JR, Konkel JE, Zangerle-Murray T, et al. Macrophages in gastrointestinal homeostasis and inflammation[J]. Pflugers Archiv: European Journal of Physiology, 2017, 469(3-4): 527-539.
[23] Xu M, Cen M, Chen X, et al. Correlation between Serological Biomarkers and Disease Activity in Patients with Inflammatory Bowel Disease[J]. BioMed Research International, 2019, 2019: 6517549.
[24] Cherfane CE, Gessel L, Cirillo D, et al. Monocytosis and a Low Lymphocyte to Monocyte Ratio Are Effective Biomarkers of Ulcerative Colitis Disease Activity[J]. Inflammatory Bowel Diseases, 2015, 21(8): 1769-1775.
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