Research on the Anti-Tumor Mechanism of Artocarpus Lingnanensis Lectin

Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i1.1805

Lu Li1, Wenya Chen2, Xiangling Li3, Ben Chen4

1. Science Experiment Center of Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China; Key Laboratory of Guangxi Traditional Chinese Medicine Basic Research, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China
2. School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China
3. Key Laboratory of Guangxi Traditional Chinese Medicine Basic Research, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China
4. Science Experiment Center of Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China

Abstract

The purpose of this study was to investigate the mechanism of Artocarpus Lingnanensis Lectin (ALL) in inhibiting the growth of tumor cells EL-4. ALL was applied to mouse lymphoma cells EL-4, with PHA (100μg/mL) as a positive control drug. The toxicity of ALL (3.125, 6.25, 12.5, 25, 50, 100, 200μg/mL) on EL-4 cells was evaluated using the CCK-8 assay. Flow cytometry was used to assess the effect of ALL (25, 100 μg/ mL) on apoptosis and cell membrane potential of EL-4 cells. Western blotting was conducted to measure the protein expression levels of BAX, cleaved-Caspase-3, cleaved-Caspase-9, cleaved-PARP1. Fluorescence microscopy was employed to detect the concentration of free calcium ions. Results showed that compared to the control group, ALL had a significant inhibitory effect on EL-4 cells in a dose-dependent manner, with an IC50 value of 105.4μg/mL. Flow cytometry results indicated an increase in apoptosis rate of EL-4 cells with ALL treatment, leading to a higher proportion of depolarized mitochondrial membrane potential. Furthermore, the protein expression levels of BAX, cleaved-Caspase-3, cleaved-Caspase-9, and cleaved-PARP1 were significantly upregulated. In conclusion, ALL can promote apoptosis of EL-4 cells through the mitochondrial apoptosis pathway, inhibit their migration and invasion, and thereby exhibit anti-tumor effects.

Keywords

Artocarpus Lingnanensis Lectin, EL-4 cells, proliferation, mitochondrial apoptosis

Funding

Guangxi Higher Education Young Teachers’ Basic Ability Enhancement Project (Grant No. 2020KY07002), School-level Project of Guangxi University of Chinese Medicine (Grant No. 2017QN016)

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