ANO1表达的多层级调控机制及其在肿瘤中的作用
Journal: Frontier Forum of Clinical Medicine DOI: 10.32629/ffcr.v4i2.19976
Abstract
Anoctamin1(ANO1)是钙激活氯离子通道,参与上皮分泌、平滑肌收缩及细胞稳态,并与肿瘤发生发展相关。ANO1在肿瘤中的表达受多层次机制调控：基因扩增、转录调控、表观遗传调控、翻译后修饰。本文就ANO1多层次调控机制及其作为肿瘤诊断标志物与治疗靶点的潜在价值作一综述。
Keywords
ANO1(TMEM16A)；表达调控；肿瘤；诊断；治疗
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[4] KUMAR S, SINGH A, GUPTA M, et al. TMEM16A in prostate cancer: mechanistic insights and therapeutic implications [J].Cancer Cell International,2025,25(1):142.
[5] SHIN Y, KIM S, LEE H, et al. Promoter hypermethylation as a novel regulator of ANO1 expression and function in pros tate cancer bone metastasis[J].Journal of Cancer Research and Clinical Oncology,2024,150(7):1891-1903.
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[26] SINGH P,LI F J,DSOUZA K,et al.Low dose cadmium expos ure regulates miR-381-ANO1 interaction in airway epithelial cells[J].Scientific Reports,2024,14:246.
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