苦苣菜调控TLR4/NF-κB信号通路干预非酒精性脂肪性肝病的研究进展
Journal: Frontier Forum of Clinical Medicine DOI: 10.32629/ffcr.v4i1.19861
Abstract
非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）是全球最常见的慢性肝病之一，其发病率随着肥胖和代谢综合征的流行而持续攀升。近年来，NAFLD已被重新命名为代谢功能障碍相关脂肪性肝病（metabolic dysfunction-associated steatotic liver disease，MASLD），以更好地反映其代谢本质。Toll样受体4（TLR4）/核因子-κB（NF-κB）信号通路在NAFLD的发生发展中发挥着关键的调控作用，该通路介导了肠-肝轴中脂多糖（LPS）诱导的炎症反应、氧化应激及脂质代谢紊乱等多个病理过程。苦苣菜（Sonchus oleraceus L.）作为一种药食同源的传统中草药，富含黄酮类、倍半萜类和酚类化合物等多种生物活性成分，具有显著的抗炎、抗氧化和保肝作用。本文系统综述了TLR4/NF-κB信号通路在NAFLD发病机制中的研究进展、天然产物通过该通路干预NAFLD的最新成果，以及苦苣菜在肝脏保护方面的药理学研究现状，旨在为NAFLD的防治提供新的思路和理论依据。
Keywords
非酒精性脂肪性肝病；TLR4/NF-κB信号通路；天然产物；苦苣菜；肠-肝轴。
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