穿心莲现代栽培技术与分子生药学进展

Journal: Frontiers of Chinese Medicine Research DOI: 10.32629/fcmr.v8i2.20945

石君静1, 林刿2, 胡晓玲3, 陆有文4, 陈苗1

1. 广东海洋大学滨海农业学院
2. 雷州市农业技术推广中心
3. 廉江市农业技术推广中心
4. 遂溪县植物检疫与病虫测报站

Abstract

穿心莲是我国传统大宗中药材,主要活性成分穿心莲内酯具有抗炎、抗菌、抗病毒等 多种药理活性。近年来,随着现代生物技术的快速发展,穿心莲研究在栽培技术和分 子生药学两个方向取得了显著进展。本文系统梳理了穿心莲在现代栽培技术(包括栽 培生理生态、栽培模式创新)和分子生药学(包括种质资源分子鉴定、次生代谢调控 机制)等方面的研究进展,分析了当前研究存在的主要问题,并对未来研究方向进行了 展望。

Keywords

穿心莲;穿心莲内酯;现代栽培技术;分子生药学;次生代谢

Funding

湛江市科技计划项目(2021A05221)穿心莲绿色高效栽培技术示范和推广;广东省重点 领域研发计划资助项目(项目名称:植物药的活性成分规模化绿色生物制造关键技术与应 用示范,项目编号:2022B1111070005);湛江市科技计划项目(2022A01206)基于品种、农 艺、装备的高良姜生产全程机械化技术体系构建与应用示范。

References

[1] 国家药典委员会.中华人民共和国药典(一部)[M].北京:中国医药科技出版社,2020 .
[2] 张龙,李静宇,徐世强,等.穿心莲分子生药学研究进展[J].中国中药杂志,2024,49( 13):3432-3440.
[3] 李静宇,孙铭阳,徐世强,等.穿心莲R2R3- MYB基因家族的鉴定与表达分析[J].中国中药杂志,2022,47(1):72-84.
[4] 孙铭阳,徐世强,李静宇,等.UV- C处理穿心莲转录组分析及穿心莲内酯合成相关基因挖掘[J].南方农业学报,2022,53(3) :618-627.
[5] HiremathC,GreeshmaM,GuptaN,et al.Morphometric, chemotypic, and molecular diversity studies in Andrographis paniculata[J].Journal of Herbs Spices and Medicinal Plants,2021,27(2):109-122.
[6] 王雨霞,邹秀崽,李春雨,等.穿心莲种质产量性状与药用成分分析[J].中山大学学报 (自然科学版),2023,62(3):100-108.
[7] ZhangL,YungWS, Hu YF,et al.Establishment of a convenient ChIP-seq protocol for identification of the histone modification regions in the medicinal plant Andrographis paniculata[J].Medicinal Plant Biology,2023,2:6.
[8] 刘叶,莫世伦,何丽燕,等.不同种质穿心莲对干旱胁迫的响应情况研究[J].分子植物 育种,2024,22(15):1-10.
[9] YodphetB,RiddechN, Kaewpradit W,et al.Effect of microbial biofertilizer on proteomic profiling, antioxidant enzyme and andrographolide content in Andrographis paniculata under drought stress[J].Plant Stress,2025,16:100817.
[10] Jian SF,Huang YF,Wan S,et al.Sulfur redirects carbon metabolism to optimize nitrogen utilization and promote andrographolide biosynthesis in Andrographis paniculata seedlings[J].Current Plant Biology,2024,40:100422.
[11] Singh A,Pandey A,Agrawal SB,et al.Responses of differential nitrogen doses on biomass,biochemical, and medicinally important metabolites of Andrographis paniculata exposed to elevated level of carbon dioxide[J].Plant Physiology Reports,2024,29:1-15.
[12] 张明,陈泓志,李明.一种复合微生物菌肥对穿心莲生长、品质及土壤性质的影响[ J].中国实验方剂学杂志,2023,29(4):153-160.
[13] 洪彪,李明,徐友阳,等.连作条件下施用竹炭对穿心莲品质及土壤细菌种群结构的 影响[J].生态学杂志,2021,40(9):2812-2821.
[14] 王晓云,陈蓉,张恩慧,等.穿心莲甲羟戊酸5- 焦磷酸脱羧酶基因的克隆与表达[J].中国中药杂志,2016,41(4):636-642.
[15] 谌琴琴,李丽霞,战鹏林,等.穿心莲八氢番茄红素脱氢酶ApPDS的基因克隆及功能鉴 定[J].中国中药杂志,2015,40(19):3760-3765.
[16] LiJY,SunMY,XuSQ,et al.Identification and expression analysis of the R2R3-MYB gene family in Andrographis paniculata[J].Chinese Journal of Natural Medicines,2022,20(1):1-15.
[17] 王健,齐梦蝶,郭娟,等.穿心莲转录因子ApNAC1的克隆、亚细胞定位及原核表达[J ].中国中药杂志,2017,42(5):890-895.
[18] LiY,Shi Y,Fan Y,et al.Transcription factors participate in methyl jasmonate-induced diterpenoid biosynthesis in Andrographis paniculata[J].Current Plant Biology,2025,43:100530.
[19] Mohapatra S,Swain SC,Samal S,et al.Influence of arecanut based cropping systems and nutrient management practices on growth, flowering and yield of arecanut[J].Plant Science Today,2025,12(3):1-10.
[20] Mohapatra S,Swain SC,Samal S,et al.Biological performance and profitability study of different medicinal plants grown as intercrops in arecanut plantations[J].Plant Science Today,2025,12(3):9829.
[21] Kamil D,Bahadur A,Kumari A,et al.First report of Sclerotium delphinii causing stem rot disease on green chireta (Andrographis paniculata)[J].Australasian Plant Disease Notes,2020,15(1):44.
[22] Elaiyabharathi T,Bhanu GS,Saikumar T,et al.Comparative toxicity of certain medicinal plants against invasive chili thrips,Thrips parvispinus (Karny)[J].Plant Science Today,2025,12(1):6328.

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