以“药”转“妆”，护肤三白汤
Journal: Frontiers of Chinese Medicine Research DOI: 10.32629/fcmr.v8i2.20941
Abstract
三白汤作为一种传统中药复方,在我国拥有悠久的应用历史。本研究旨在探讨三白汤 在护肤领域的功效及其作用机制,以期为中药化妆品的研发与推广提供科学依据。研 究首先采用网络药理学和分子对接技术预测了三白汤的活性成分、关键作用靶点及 相关信号通路,结果表明其主要活性成分包括槲皮素、山奈酚、熊果酸和柚皮素等, 核心靶点涉及STAT3、AKT1、IL1B、IL6、ESR1、BCL2、TYR、TP53和EGFR等,并富集 于AGE-RAGE、PI3K-Akt、MAPK、IL-17、HIF- 1和FoxO等信号通路,提示其具有抑菌祛痘、抗氧化、抗衰老和美白功效。随后,通过 水提和醇提两种方式对三白汤进行提取,并测定了总黄酮和总三萜皂苷的含量。体外 实验、细菌实验、细胞实验、秀丽隐杆线虫模型和斑马鱼模型进一步验证了三白汤 在抑菌祛痘、抗氧化抗衰老和美白方面的功效。结果显示,三白汤醇提液对痤疮丙酸 杆菌和金黄色葡萄球菌具有显著抑菌作用,能有效清除DPPH、PTIO、ABTS和羟基自由 基,显著延长秀丽隐杆线虫寿命,改善其运动状态,并减少脂褐素积累,同时对酪氨酸 酶活性和黑色素生成具有抑制作用。最后,以Olivem1000为乳化剂,卡波940与HEC复 配为增稠剂制备了三白养颜霜,并通过鸡胚绒毛尿囊膜试验和人体斑贴试验验证了其 良好的安全性和低刺激性。本研究为三白汤在现代护肤品领域的应用提供了理论基 础和实验支持。
Keywords
三白汤；网络药理学；美白；抑菌祛痘；抗氧化；抗衰老
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[1] 李梴.医学入门[M].北京:中国医药科技出版社,1995:296.
[2] Zhao N,Su X, Wang Y,Chen J,Zhuang W.Traditional Chinese Herbal Medicine for Whitening[J].Natural Product Communications.February,2020;15(2).
[3] RU J,LI P,WANG J,et al.TCMSP:a database of systems pharmacology for drug discovery from herbal medicines[J]. Journal of Cheminformatics,2014,6(1).
[4] RENAUX A.UniProt:the universal protein knowledgebase[J].Nucleic Acids Res,2018,46(5):2699.
[5] 贾俊芳,孟德新,李淑霞,等.古方三白汤不同溶剂提取物美白作用比较研究[J].化工 设计通讯,2022,48(11):234-236.
[6] 刘子祯,姜蕊,刘伟锐,等.红枣叶中三萜皂苷的提取工艺和含量测定研究[J].食品研 究与开发,2016,37(1):57-59.
[7] SASEBOHEVY,PRAKASITA V C,ADITIYARINI D.Aktivitas Antibakteri Ekstrak Etanol Daun Binahong Terhadap Staphylococcus aureus dan Propionibacterium acnes Penyebab Jerawat[J].SCISCITATIO,2023,4(1).
[8] KRIANGKRAI W,KANTASA T,SAGASAE W,et al.Discovery of superior bioactive peptides of two edible Lentinus mushrooms protein hydrolysate in biological activities: tyrosinase inhibitory and antioxidant activity[J].Food Science and Biotechnology,2024,33(13):3105-3117.
[9] PING Z.Tyrosinase inhibition test and its application in efficacy evaluation of whitening cosmetics[Z].2022.
[2] Zhao N,Su X, Wang Y,Chen J,Zhuang W.Traditional Chinese Herbal Medicine for Whitening[J].Natural Product Communications.February,2020;15(2).
[3] RU J,LI P,WANG J,et al.TCMSP:a database of systems pharmacology for drug discovery from herbal medicines[J]. Journal of Cheminformatics,2014,6(1).
[4] RENAUX A.UniProt:the universal protein knowledgebase[J].Nucleic Acids Res,2018,46(5):2699.
[5] 贾俊芳,孟德新,李淑霞,等.古方三白汤不同溶剂提取物美白作用比较研究[J].化工 设计通讯,2022,48(11):234-236.
[6] 刘子祯,姜蕊,刘伟锐,等.红枣叶中三萜皂苷的提取工艺和含量测定研究[J].食品研 究与开发,2016,37(1):57-59.
[7] SASEBOHEVY,PRAKASITA V C,ADITIYARINI D.Aktivitas Antibakteri Ekstrak Etanol Daun Binahong Terhadap Staphylococcus aureus dan Propionibacterium acnes Penyebab Jerawat[J].SCISCITATIO,2023,4(1).
[8] KRIANGKRAI W,KANTASA T,SAGASAE W,et al.Discovery of superior bioactive peptides of two edible Lentinus mushrooms protein hydrolysate in biological activities: tyrosinase inhibitory and antioxidant activity[J].Food Science and Biotechnology,2024,33(13):3105-3117.
[9] PING Z.Tyrosinase inhibition test and its application in efficacy evaluation of whitening cosmetics[Z].2022.
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