补肾活血汤联合常规治疗对脑梗死瘀血阻络证认知及氧化应激的影响
Journal: Frontiers of Chinese Medicine Research DOI: 10.32629/fcmr.v8i1.19668
Abstract
急性缺血性卒中(AIS)后认知障碍(PSCI)严重影响患者预后,现有疗法疗效有限。本研究旨在评估补肾活血汤联合常规治疗对AIS患者认知功能及氧化应激指标的影响。采用前瞻性队列设计,将64例瘀血阻络型PSCI患者随机分为对照组(常规西药治疗)和治疗组(常规西药联合补肾活血汤),每组32例,疗程90天。主要结局指标包括蒙特利尔认知评估量表(MoCA)评分、美国国立卫生研究院卒中量表(NIHSS)评分及血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果显示,治疗后,治疗组在MoCA评分(从19.5±2.1分提升至24.8±2.5分)和NIHSS评分(从8.2±2.5分下降至3.1±1.8分)的改善均显著优于对照组(均P<0.05)。同时,治疗组血清SOD活性升高(从85.3±10.5 U/mL升至105.6±12.8U/mL)及MDA水平降低(从5.8±1.2 nmol/mL降至3.9±0.9nmol/mL)的幅度亦显著大于对照组(均P<0.05)。两组不良反应发生率无统计学差异。结论：在常规治疗基础上加用补肾活血汤可更有效地改善AIS后PSCI患者的认知与神经功能,其机制可能与增强抗氧化能力、减轻氧化应激损伤有关,且安全性良好。本研究为中西医结合治疗PSCI提供了临床依据,未来需更大规模、双盲设计的试验进一步验证。
Keywords
急性缺血性卒中；卒中后认知障碍；补肾活血汤；氧化应激；中西医结合治疗
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