冬瓜荷叶茶减肥降脂作用机制研究
Journal: Frontiers of Chinese Medicine Research DOI: 10.32629/fcmr.v1i1.346
Abstract
目的：在分子水平诠释冬瓜荷叶茶减肥降脂作用机制,阐明其传统减肥理论与现代科学理论的关系。方法：整合相关数据,构建冬瓜荷叶茶减肥降脂分子生物网络,采用现代科学理论和传统理论加以分析。结果：分子网络中共有145个节点,480条边,从中筛选得到荷叶碱等17个关键化学成分以及P18031、P37231等5个关键作用靶点。结论：冬瓜荷叶茶主要通过改善膀胱平滑肌及下尿路症状(LUTS),活化激素敏感性脂肪酶(HSL),抑制胰岛素和瘦素抵抗等多种途径发挥减肥降脂作用；这与冬瓜荷叶茶传统减肥理论相契合,有助于其传统减肥理论的“现代化”理解,可为中医药理论现代化研究提供参考依据。
Keywords
冬瓜荷叶茶；减肥降脂；作用机制；肥胖；中医药理论现代化
Funding
北京中医药大学；国家自然科学基金支持项目(批准号：81673697)
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