基于 ERP 探讨 rTMS 改善难治性抑郁症患者认知功能的疗效研究
Journal: Clinical Application Research of Nursing Care DOI: 10.32629/carnc.v4i2.20627
Abstract
目的：初步研究使用事件相关电位(Event related potential,ERP)检查探讨重复经颅磁刺激(repetitive Transcranial magnetic stimulation,rTMS)对难治性抑郁症(Treatment resistant depression,TRD)患者的症状及认知功能的改变情况。方法：选取2022年12月-2025.12月在聊城市第四人民医院住院病人80例,随机分为药物治疗组和药物联合rTMS治疗组。利用汉密尔顿抑郁量表-17(Hamitton depressionrating scale-17 items,HAMD-17)在治疗前、治疗后4周后来评估患者的抑郁量表评分。分别在治疗前与治疗第4周末,使用蒙特利尔认知评估量表(MoCA)评估患者认知功能状况,同期开展事件相关电位检测以获取神经电生理指标。比较两组受试者认知电位P300刺激下N2、P2、P3波的潜伏期及波幅变化。结果:两组经治疗后HAMD-17评分、MoCA量表评分较前均、P300潜伏期缩短、波幅变高。药物治疗组+伪刺激治疗组HAMD-17评分、MoCA量表评分均较药物联合rTMS治疗组高(P＜0.05)。药物治疗组+伪刺激治疗组N2、P3a、P3b潜伏期较药物联合rTMS治疗组长(P＜0.05),P3a、P3b波幅较药物联合rTMS治疗组低(P＜0.05)。结论：视觉P300的P3潜伏期及波幅联合分析,可为rTMS治疗难治性抑郁症的疗效监测提供参考依据。rTMS对于TRD有改善抑郁症状和认知功能的功能。
Keywords
难治性抑郁症；重复经颅磁刺激；事件相关电位；认知功能
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