脂肪组织炎症在冠状动脉粥样硬化中的机制研究进展
Journal: Basic Medical Theory Research DOI: 10.32629/bmtr.v8i3.20476
Abstract
冠状动脉粥样硬化性心脏病(冠心病)是全球范围内导致死亡和残疾的主要疾病之一。近年来,脂肪组织不仅仅是能量储存器官,更是活跃的内分泌和免疫器官,通过分泌多种生物活性因子参与冠心病发生发展的观点日益受到重视。本文系统综述了心外膜脂肪组织、血管周围脂肪组织等特定脂肪库的炎症反应在冠心病发病机制中的作用,深入探讨了炎症因子分泌失衡、免疫细胞活化及相关信号通路在促进冠状动脉粥样硬化过程中的关键机制,并总结了基于脂肪组织炎症的潜在治疗靶点和临床干预策略。理解脂肪组织炎症在冠心病中的作用,对于开发新的防治策略具有重要意义。
Keywords
冠心病;心外膜脂肪组织;血管周围脂肪组织;脂肪组织炎症;动脉粥样硬化
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[25] Gonzalez-Hurtado E, Leveau C, Li K, et al. Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation[J]. Nature aging, 2025,5(9):1828-1843.
[26] Yang Y, Huang B, Qin Y, et al. Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity[J]. eLife, 2024,13:e99162.
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