光固化水凝胶装载外泌体促进成骨的实验研究
Journal: Basic Medical Theory Research DOI: 10.32629/bmtr.v8i3.20427
Abstract
目的：验证甲基丙烯酸酐化明胶装载外泌体结合骨折内固定物促进成骨可行性。方法：制备装载外泌体的甲基丙烯酸酐化明胶涂层，进行基本性能测试，根据性能要求改良制备技术，检测其装载及释放外泌体的效能。检测涂层的细胞相容性、促进骨髓基质干细胞成骨的效果，使用SPSS16.0软件进行统计分析，计量资料以均数±标准差表示，组间比较采用组间方差分析。结果：载外泌体水凝胶涂层的光固化性能，粘附力及细胞相容性良好，装载及释放外泌体效能稳定，促成骨效果良好。结论：新型外泌体水凝胶缓涂层能够增加局部的成骨效果，通过其结合于内固定表面促进成骨的思路是可行的，可为进一步深入研究奠定基础。
Keywords
甲基丙烯酸酐化明胶；诱导成骨；外泌体
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