秋水仙碱对冠脉 PCI 术后患者高敏 c 反应蛋白的影响
Journal: Basic Medical Theory Research DOI: 10.32629/bmtr.v8i1.18656
Abstract
目的:本研究观察秋水仙碱联合标准治疗对冠脉PCI术后患者高敏c反应蛋白(hsCRP)的影响和临床疗效。方法:选择2023年6月-2024年6月在重庆市璧山区人民医院心血管内科内行冠脉PCI患者100例。随机分为对照组(50例)和秋水仙碱组(50例),对照组给予冠心病标准治疗,秋水仙碱组是在对照组基础上加用秋水仙碱。对比两组数据,观察PCI术后hsCRP浓度。结果:术后24小时:秋水仙碱组hsCRP变化率中位数(13.2%)仅为对照组(68.5%)的19.3%。术后1周:秋水仙碱组hsCRP变化率中位数(-3.5%)呈负向(接近基线),而对照组仍为正向升高(45.3%)。
Keywords
秋水仙碱;冠状动脉粥样硬化性心脏病;冠状动脉pci;高敏c反应蛋白
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[1] 中华医学会心血管病学分会。经皮冠状动脉介入治疗术后管理中国专家共识(2023版)[J].中华心血管病杂志,2023,51(5):421-432.
[2] Jernberg T,Hasvold P,Henriksson M,et al. Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term persp ective[J].Eur Heart J 2015;36:1163-70.
[3] Ross R. Atherosclerosis--an inflammatory disease[J]. N Engl J Med 1999;340:115-26.
[4] 李为民,韩雅玲.老年冠心病患者经皮冠状动脉介入治疗中国专家共识(2022)[J].中华老年心脑血管病杂志,2022,24(8):801-806.
[5] deWinterRJ, Heyde GS, Koch KT, et al. The prognostic value of preprocedural plasma C-reactive protein in patients undergoing elective coronary angioplasty[J].Eur Heart J 2002;23:960-6.
[6] Arroyo-Espliguero R, Avanzas P, Cosín-Sales J, et al. C-reactive protein elevation and disease activity in patients with coronary artery disease[J]. Eur Heart J 2004;25:401-8.
[7] Habib M,Salama I,Agha HA, et al. Colchicine treatment for prevention of in stent restenosis (CISR trial)[J]. American J Emerg Crit Care Med 2019;2:001-5.
[8] Ren F, Mu N,Zhang X,Tan J,Li L,Zhang C,Dong M. Increased platelet-leukocyte aggregates are associated with myocardial no-reflow in patients with ST elevation myocardial infarction [J].Am J Med Sci.2016;352:261-6.
[9] Robertson S, Martínez GJ, Payet CA, et al. Colchicine therapy in acute coronary syndrome patients acts on caspase -1 to suppress NLRP3 inflammasome monocyte activation[J].Clin Sci 2016;130:1237-46.
[10] Patti G, Chello M, Pasceri V,et al. Protection from procedural myocardial injury by atorvastatin is associated with lower levels of adhesion molecules after PCI [J]. J Am Coll Cardiol,2006,48(7):1560-1566.
[11] Paschke S,Weidner AF,Paust T,et al.Inhibition of neut rophil chemotaxis by colchicine is modulated through viscoel astic properties of subcellular compartments[J]. J Leukoc Biol,2013,94(5):1091-1096.
[12] Martinon F, Pétrilli V, Mayor A, et al. Gout-associated uric acid crystals activate the NALP3 inflammasome [J]. Nature,2006,440(7081):237-241.
[13] Gotz AK,Zahler S,Stumpf P,et al.Intracoronary format ion and retention of micro aggregates of leukocytes and plate lets contribute to postischemic myocardial dysfunction[J].Basic Res Cardiol,2005,100(5):413-421.
[2] Jernberg T,Hasvold P,Henriksson M,et al. Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term persp ective[J].Eur Heart J 2015;36:1163-70.
[3] Ross R. Atherosclerosis--an inflammatory disease[J]. N Engl J Med 1999;340:115-26.
[4] 李为民,韩雅玲.老年冠心病患者经皮冠状动脉介入治疗中国专家共识(2022)[J].中华老年心脑血管病杂志,2022,24(8):801-806.
[5] deWinterRJ, Heyde GS, Koch KT, et al. The prognostic value of preprocedural plasma C-reactive protein in patients undergoing elective coronary angioplasty[J].Eur Heart J 2002;23:960-6.
[6] Arroyo-Espliguero R, Avanzas P, Cosín-Sales J, et al. C-reactive protein elevation and disease activity in patients with coronary artery disease[J]. Eur Heart J 2004;25:401-8.
[7] Habib M,Salama I,Agha HA, et al. Colchicine treatment for prevention of in stent restenosis (CISR trial)[J]. American J Emerg Crit Care Med 2019;2:001-5.
[8] Ren F, Mu N,Zhang X,Tan J,Li L,Zhang C,Dong M. Increased platelet-leukocyte aggregates are associated with myocardial no-reflow in patients with ST elevation myocardial infarction [J].Am J Med Sci.2016;352:261-6.
[9] Robertson S, Martínez GJ, Payet CA, et al. Colchicine therapy in acute coronary syndrome patients acts on caspase -1 to suppress NLRP3 inflammasome monocyte activation[J].Clin Sci 2016;130:1237-46.
[10] Patti G, Chello M, Pasceri V,et al. Protection from procedural myocardial injury by atorvastatin is associated with lower levels of adhesion molecules after PCI [J]. J Am Coll Cardiol,2006,48(7):1560-1566.
[11] Paschke S,Weidner AF,Paust T,et al.Inhibition of neut rophil chemotaxis by colchicine is modulated through viscoel astic properties of subcellular compartments[J]. J Leukoc Biol,2013,94(5):1091-1096.
[12] Martinon F, Pétrilli V, Mayor A, et al. Gout-associated uric acid crystals activate the NALP3 inflammasome [J]. Nature,2006,440(7081):237-241.
[13] Gotz AK,Zahler S,Stumpf P,et al.Intracoronary format ion and retention of micro aggregates of leukocytes and plate lets contribute to postischemic myocardial dysfunction[J].Basic Res Cardiol,2005,100(5):413-421.
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