细胞焦亡在脓毒症致多器官功能衰竭中的病理机制及研究进展
Journal: Basic Medical Theory Research DOI: 10.32629/bmtr.v8i1.18594
Abstract
脓毒症是指机体对感染反应失调所引起的危及生命的器官功能障碍,而多器官功能衰竭是其主要死因。细胞焦亡作为一种由Gasdermin家族蛋白介导的程序性细胞死亡方式,已经被证实为脓毒症进程当中的关键环节。本文系统叙述了目前研究中细胞焦亡在脓毒症中的分子机制,并重点阐述了其在诱导内皮细胞损伤、微循环障碍及各个器官功能衰竭的重要作用。同时,探讨了从抗细胞焦亡角度治疗脓毒症策略的潜力和挑战。
Keywords
脓毒症；多器官功能衰竭；细胞焦亡；Gasdermin D；炎症小体
Full Text
PDF - Viewed/Downloaded: 1 TimesReferences
[1] SU J, WU S, ZHOU F. Research Progress of Macromolecules in the Prevention and Treatment of Sepsis.[J/OL]. Internatio nal journal of molecular sciences,2023,24(16).
[2] BORGES A, BENTO L. Organ crosstalk and dysfunction in sepsis[J/OL].Annals of intensive care,2024,14(1):147.
[3] VIGNERON C, PY B F,MONNERET G.The double sides of NLR P3 inflammasome activation in sepsis.[J/OL]. Clinical science (London, England:1979),2023,137(5):333-351.
[4] LIU X,LIEBERMAN J.Inflammasome-independent pyropto sis[J/OL].Current opinion in immunology,2024,88:102432.
[5] ZHANG W J,LI K Y, LAN Y,.NLRP3 Inflammasome:A key contr ibutor to the inflammation formation.[J/OL].Food and chemic al toxicology : an international journal published for the British Industrial Biological Research Association, 2023, 174:113683.
[6] BURDETTE B E,ESPARZA A N,ZHU H.Gasdermin D in pyropto sis[J/OL].Acta pharmaceutica Sinica.B,2021,11(9):2768-2782.
[7] WU J,CAI J,TANG Y.The noncanonical inflammasome-indu ced pyroptosis and septic shock.[J/OL].Seminars in immunology,2023,70:101844.
[8] HUANG L Y,GUO S F,HOU Y Q.[Research progress on pyropt osis in sepsis-induced organ injury].[J/OL]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2025,59(7):1141-1147.
[9] WEN R,LIU Y P,TONG X X.Molecular mechanisms and funct ions of pyroptosis in sepsis and sepsis-associated organ dys function[J/OL].Frontiers in cellular and infection microbiolo gy,2022,12:962139.
[10] QU M,WANG Y,QIU Z.Necroptosis,Pyroptosis, Ferroptosis in Sepsis and Treatment.[J/OL]. Shock (Augusta, Ga.),2022,57(6):161-171.
[11] SHAO R, LOU X, XUE J,. Review: the role of GSDMD in sepsis.[J/OL]. Inflammation research : official journal of the European Histamine Research Society...[et al.],2022,71(10-11):
[12] XIAO C, LI X. Pyroptosis and sepsis-associated acute kidney injury.[J/OL]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2024,49(8):1333-1340.
[13] WEN R,ZHANG T N,YANG N.[Recent research on pyropt osis in sepsis-induced myocardial depression].[J/OL]. Zhongg uo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,2024,26(7):774-781.
[14] YANG H,ZHANG Z.Sepsis-induced myocardial dysfuncti on:the role of mitochondrial dysfunction.[J/OL]. Inflammation research : official journal of the European Histamine Research Society...[et al.],2021,70(4):379-387.
[15] SJAASTAD F V, KUCABA T A, DILEEPAN T. Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity.[J/OL].Frontiers in immunology,2020,11:1786.
[2] BORGES A, BENTO L. Organ crosstalk and dysfunction in sepsis[J/OL].Annals of intensive care,2024,14(1):147.
[3] VIGNERON C, PY B F,MONNERET G.The double sides of NLR P3 inflammasome activation in sepsis.[J/OL]. Clinical science (London, England:1979),2023,137(5):333-351.
[4] LIU X,LIEBERMAN J.Inflammasome-independent pyropto sis[J/OL].Current opinion in immunology,2024,88:102432.
[5] ZHANG W J,LI K Y, LAN Y,.NLRP3 Inflammasome:A key contr ibutor to the inflammation formation.[J/OL].Food and chemic al toxicology : an international journal published for the British Industrial Biological Research Association, 2023, 174:113683.
[6] BURDETTE B E,ESPARZA A N,ZHU H.Gasdermin D in pyropto sis[J/OL].Acta pharmaceutica Sinica.B,2021,11(9):2768-2782.
[7] WU J,CAI J,TANG Y.The noncanonical inflammasome-indu ced pyroptosis and septic shock.[J/OL].Seminars in immunology,2023,70:101844.
[8] HUANG L Y,GUO S F,HOU Y Q.[Research progress on pyropt osis in sepsis-induced organ injury].[J/OL]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2025,59(7):1141-1147.
[9] WEN R,LIU Y P,TONG X X.Molecular mechanisms and funct ions of pyroptosis in sepsis and sepsis-associated organ dys function[J/OL].Frontiers in cellular and infection microbiolo gy,2022,12:962139.
[10] QU M,WANG Y,QIU Z.Necroptosis,Pyroptosis, Ferroptosis in Sepsis and Treatment.[J/OL]. Shock (Augusta, Ga.),2022,57(6):161-171.
[11] SHAO R, LOU X, XUE J,. Review: the role of GSDMD in sepsis.[J/OL]. Inflammation research : official journal of the European Histamine Research Society...[et al.],2022,71(10-11):
[12] XIAO C, LI X. Pyroptosis and sepsis-associated acute kidney injury.[J/OL]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2024,49(8):1333-1340.
[13] WEN R,ZHANG T N,YANG N.[Recent research on pyropt osis in sepsis-induced myocardial depression].[J/OL]. Zhongg uo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,2024,26(7):774-781.
[14] YANG H,ZHANG Z.Sepsis-induced myocardial dysfuncti on:the role of mitochondrial dysfunction.[J/OL]. Inflammation research : official journal of the European Histamine Research Society...[et al.],2021,70(4):379-387.
[15] SJAASTAD F V, KUCABA T A, DILEEPAN T. Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity.[J/OL].Frontiers in immunology,2020,11:1786.
Copyright © 2026 王子燕, 张坤
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License