急性一氧化碳中毒迟发性脑病免疫学机制研究进展
Journal: Basic Medical Theory Research DOI: 10.32629/bmtr.v2i3.1674
Abstract
一氧化碳中毒是急诊科常见的中毒性疾病,可同时并发多种严重疾病,极大地影响着人们的健康。其中,一氧化碳中毒后迟发性脑病是一氧化碳中毒最常见的并发症,严重影响患者后期的生活质量。关于一氧化碳中毒机制的学说有很多,但目前尚无统一定论。一氧化碳中毒后迟发性脑病的发病机制大致可以归纳为以下几种学说：免疫反应学说、缺血缺氧学说、细胞凋亡与细胞自噬学说、缺血-再灌注及自由基损伤学说、兴奋性氨基酸学说等。我们对该病发病机制进行综述,以便为今后预测一氧化碳中毒后迟发性脑病提供新的方法和新思路。
Keywords
急性一氧化碳中毒；一氧化碳中毒迟发性脑病；免疫学机制
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[16] Jang DH, Kelly M, Hardy K, etal. A preliminary study in thealterations of mitochondrial respirationin patients with carbon monoxidepoisoning measured in blood cells[J].Clinical toxicology (Philadelphia, Pa),2017,55(6):579-584.
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[18] 黄博雅.高压氧对一氧化碳中毒迟发性脑病小鼠的影响及机制的研究[D].内蒙古医科大学,2017.
[19] 曹义战,李金声,晋兴,等.急性一氧化碳中毒大鼠迟发性神经元损伤与记忆功能改变[J].中国急救医学,2002,22(10):569-571.
[20] 李晟,陈潜妙,池学锋,等.急性一氧化碳中毒后迟发性脑病预测因子的研究[J].浙江医学,2019,41(11):1150-1153.
[21] Goda N, Ryan HE, Khadivi B, etal. Hypoxia-inducible factor 1alpha isessential for cell cycle arrest duringhypoxia[J].Mol Cell Biol,2003,23(1):359-369.
[22] Hynd MR, Scott HL, Dodd PR.Glutamate-mediated excitotoxicity andneurodegeneration in Alzheimer's disease[J].NeurochemInt,2004,45(5):583-595.
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