Synchronous multiple primary pulmonary neoplasms. hamartoma as the main tumor and pulmonary adenocarcinoma
Journal: Advances in Medicine and Engineering Interdisciplinary Research DOI: 10.32629/ameir.v4i1.4935
Abstract
The presence of the multiple primary lung neoplasms is a rare event, with few series described in the literature. These can manifest synchronously, or metachronous, the latter being is the most common. The prognosis in the patients with synchronous tumors appears to be more unfavorable than in the patients with a single lung neoplasm. Method: Because it involved bioethical aspects, the research complied with the ethical-bioethical principles, was carried out attentive to ethical-moral objections, and also under the focus of the current regulations (requirements of the Good Clinical Practices-GCP-, and adherence to ethical-bioethical principles originating in the Helsinki Declaration and the habeas data law). The Informed consent was obtained from the patient through which all information about the risks and the benefits was provided, as well as full autonomy to accept or reject the research as well as anonymity. Likewise, the case was approved by the bioethics committee. Clinical case: Patient with a preoperative histopathological diagnosis of hamartoma-type lung neoplasia. The surgery was carried out through the right lower lobectomy through posterolateral thoracotomy (Sweet). The postoperative evolution was satisfactory and the pathological and the immunohistochemical diagnosis reported primary multiple pulmonary neoplasia hamartoma and adenocarcinoma as the synchronous one, the two lesions being of different origin. Conclusion. The multiple primary lung neoplasia is a rare form of presentation, such as at the hamartoma with focal acinar-type lung adenocarcinoma, which is difficult to diagnose on certain occasions and has a reserved prognosis.
Keywords
multiple primary neoplasia; lung; hamartoma; synchronous
Full Text
PDF - Viewed/Downloaded: 0 TimesReferences
[1] Ramos-Clemente Romero JI, Pérez Ramos MA, Benavente Fernández A, Romero Jiménez MJ, Martínez García R, Barrios Merino A. Neoplasia primaria múltiple sincrónica de pulmón. An. Med. Interna (Madrid) [Internet]. 2006;23(2):93-94. Disponible en: URL: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-71992006000200010&lng=es.
[2] Chanel S, Burke L, Fiche M, Molina T, Lerochais JP, Icard P, et al. Synchronous pulmonary adenocarcinoma and extranodal marginal zone/low-grade B-cell lymphoma of MALT type. Hum Pathol. 2001;32(1):129-132.
[3] Loukeri AA, Kampolis CF, Ntokou A, Tsoukalas G, Syrigos K. Metachronous and synchronous primary lung cancers: Diagnostic aspects, surgical treatment, and prognosis. Clin Lung Cancer. 2015;16(1):15-23.
[4] Pascua JR, Di Tullio G, Samudio F, Méndez M, Auvieux JR, et al. Adenocarcinoma pulmonar sincrónico y linfoma primario de tejido linfoide asociado a mucosa pulmonar. Medicina (B. Aires) [Internet]. 2019;79(3):208-211. Disponible en: URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802019000500010&lng=es.
[5] Gutiérrez Lara G, Lea Pereira MC, Dones Carvajal JJ. Neoplasia primaria múltiple pulmonar. Med Integral 2002;40(7):305309. Disponible en: URL: https://www.elsevier.es/es-revista-medicina-integral-63-articulo-neoplasia-primaria-multiple-pulmonar-13038578.
[6] Dohmoto K, Fujita J, Ohtsuki Y, Kotsuna N, Mitsunaka H, Kuwabara H, et al. Synchronous four primary lung adenocarcinoma associated with multiple atypical adenomatous hyperplasia. Lung Cancer. 2000;27(2):125-130.
[7] Colomer EJ, Molina JC, Aguilar X, Magardas R, Mayayo E, Richart C. Neoplasia primaria múltiple pulmonar sincrónica: carcinoma microcítico como tumor principal y carcinoma epidermoide, una asociación infrecuente. Arch Bronconeumol 1999; 35:241-247. Disponible en: URL: https://www.archbronconeumol.org/en-estadisticas-S0300289615302635.
[8] Villarroel SJC, Castro RS, Precerutti AJA. Neoplasia primaria múltiple sincrónica de pulmón. Revista del Hospital Italiano de Buenos Aires. Disponible en: URL: https://instituto.hospitalitaliano.org.ar/multimedia/archivos/noticias_attachs/47/documentos/18536_100-101-HI3-6-Imagen-Villarroel-A.pdf.
[9] Heras Alonso MM, Gelabert Mas A. Tumores primarios múltiples independientes y segundas neoplasias primarias: Relación con el hábito de fumar. Actas Urol Esp [Internet]. 2010;34(6):516-521. Disponible en: URL: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0210-48062010000600005&lng=es.
[10] Kashif M, Ayyadurai P, Thanha L, Khaja M. Triple synchronous primary lung cancer: A case report and review of the literature. J Med Case Rep. 2017;11(1):245.
[11] Yoon HJ, Lee HY, Han J, Choi YL. Cánceres de pulmón primarios triples sincrónicos: informe de un caso. Korean J Radiol. 2014; 15 (5):646-650.
[12] Las Heras Al, Gelabert GA. Tumores primarios múltiples independientes y segundas neoplasias primarias. Relación con el hábito de fumar. Actas Urol Esp. 2010; 34(6) :516-521. Disponible en: URL: https:// scielo.isciii.es/pdf/aue/v34n6/especial2.pdf.
[13] Teppo L, Salminen E, Pukkala E. Risk of a new primary cancer among patients with lung cancer of different histological types. Eur J Cancer. 2001;37(5):613-619.
[14] Márquez Navarro J. Cáncer de pulmón como segunda neoplasia. (Tesis Doctoral Inédita). Universidad de Sevilla, Sevilla. (1990). Disponible en: URL: https://dialnet.unirioja.es/servlet/tesis?codigo=262171.
[15] Migliaro M, Ballard DH, Takalkar A, Thomas-Ogunniyi JO, Previgliano CH, Gonzalez-Toledo E. Synchronous primary lung cancer with adenocarcinoma and squamous cell carcinoma in the right upper lobe. Am J Med Sci. 2016;352(4):427.
[16] Guerra Mesa JL, González Hernández J, Bosque Diego OJ, Flores Vega YI, Rodríguez Machado J, Galainena J. Combinación poco frecuente de neoplasias múltiples sincrónicas. Rev cubana Cir [Internet]. 2016;55(2). Disponible en: URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-74932016000200010.
[2] Chanel S, Burke L, Fiche M, Molina T, Lerochais JP, Icard P, et al. Synchronous pulmonary adenocarcinoma and extranodal marginal zone/low-grade B-cell lymphoma of MALT type. Hum Pathol. 2001;32(1):129-132.
[3] Loukeri AA, Kampolis CF, Ntokou A, Tsoukalas G, Syrigos K. Metachronous and synchronous primary lung cancers: Diagnostic aspects, surgical treatment, and prognosis. Clin Lung Cancer. 2015;16(1):15-23.
[4] Pascua JR, Di Tullio G, Samudio F, Méndez M, Auvieux JR, et al. Adenocarcinoma pulmonar sincrónico y linfoma primario de tejido linfoide asociado a mucosa pulmonar. Medicina (B. Aires) [Internet]. 2019;79(3):208-211. Disponible en: URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802019000500010&lng=es.
[5] Gutiérrez Lara G, Lea Pereira MC, Dones Carvajal JJ. Neoplasia primaria múltiple pulmonar. Med Integral 2002;40(7):305309. Disponible en: URL: https://www.elsevier.es/es-revista-medicina-integral-63-articulo-neoplasia-primaria-multiple-pulmonar-13038578.
[6] Dohmoto K, Fujita J, Ohtsuki Y, Kotsuna N, Mitsunaka H, Kuwabara H, et al. Synchronous four primary lung adenocarcinoma associated with multiple atypical adenomatous hyperplasia. Lung Cancer. 2000;27(2):125-130.
[7] Colomer EJ, Molina JC, Aguilar X, Magardas R, Mayayo E, Richart C. Neoplasia primaria múltiple pulmonar sincrónica: carcinoma microcítico como tumor principal y carcinoma epidermoide, una asociación infrecuente. Arch Bronconeumol 1999; 35:241-247. Disponible en: URL: https://www.archbronconeumol.org/en-estadisticas-S0300289615302635.
[8] Villarroel SJC, Castro RS, Precerutti AJA. Neoplasia primaria múltiple sincrónica de pulmón. Revista del Hospital Italiano de Buenos Aires. Disponible en: URL: https://instituto.hospitalitaliano.org.ar/multimedia/archivos/noticias_attachs/47/documentos/18536_100-101-HI3-6-Imagen-Villarroel-A.pdf.
[9] Heras Alonso MM, Gelabert Mas A. Tumores primarios múltiples independientes y segundas neoplasias primarias: Relación con el hábito de fumar. Actas Urol Esp [Internet]. 2010;34(6):516-521. Disponible en: URL: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0210-48062010000600005&lng=es.
[10] Kashif M, Ayyadurai P, Thanha L, Khaja M. Triple synchronous primary lung cancer: A case report and review of the literature. J Med Case Rep. 2017;11(1):245.
[11] Yoon HJ, Lee HY, Han J, Choi YL. Cánceres de pulmón primarios triples sincrónicos: informe de un caso. Korean J Radiol. 2014; 15 (5):646-650.
[12] Las Heras Al, Gelabert GA. Tumores primarios múltiples independientes y segundas neoplasias primarias. Relación con el hábito de fumar. Actas Urol Esp. 2010; 34(6) :516-521. Disponible en: URL: https:// scielo.isciii.es/pdf/aue/v34n6/especial2.pdf.
[13] Teppo L, Salminen E, Pukkala E. Risk of a new primary cancer among patients with lung cancer of different histological types. Eur J Cancer. 2001;37(5):613-619.
[14] Márquez Navarro J. Cáncer de pulmón como segunda neoplasia. (Tesis Doctoral Inédita). Universidad de Sevilla, Sevilla. (1990). Disponible en: URL: https://dialnet.unirioja.es/servlet/tesis?codigo=262171.
[15] Migliaro M, Ballard DH, Takalkar A, Thomas-Ogunniyi JO, Previgliano CH, Gonzalez-Toledo E. Synchronous primary lung cancer with adenocarcinoma and squamous cell carcinoma in the right upper lobe. Am J Med Sci. 2016;352(4):427.
[16] Guerra Mesa JL, González Hernández J, Bosque Diego OJ, Flores Vega YI, Rodríguez Machado J, Galainena J. Combinación poco frecuente de neoplasias múltiples sincrónicas. Rev cubana Cir [Internet]. 2016;55(2). Disponible en: URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-74932016000200010.
Copyright © 2026 Juan Carlos Araujo-Cuauro, Milagros Sánchez De Rosales
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License