Corynebacterium Kroppenstedtii Breast Infections: Report of Four Cases
Journal: Advances in Medicine and Engineering Interdisciplinary Research DOI: 10.32629/ameir.v3i1.3455
Abstract
Corynebacterium kroppenstedtii is an immobile, non-sporulated, glucose-fermenting and lipophilic gram-positive bacillus of the skin microbiota. In recent years, numerous isolates of this species have been reported mainly in breast infections, such as abscesses and granulomatous mastitis. We present here four cases of C. kroppenstedtii infections isolated from breast aspiration samples in women. C. kroppenstedtii was identified by conventional methods and mass spectrometry (MALDI-TOF MS). Using the epsilometric method, these isolates showed susceptibility to penicillin, ceftriaxone, minocycline, ciprofloxacin, and vancomycin, and variable susceptibility to clindamycin and trimethoprim sulfamethoxazole. Due to the association of C. kroppenstedtii with mammary infections, the identification at the species level of those corynebacteria isolated from this location is highly advisable in order to reach the final diagnosis and to test the antimicrobial susceptibility in order to apply the appropriate antibiotic treatment.
Keywords
corynebacterium kroppenstedtii; breast infections; granulomatous mastitis; lipophilic species
Funding
This work has been funded by the UBACYT 2018 Project Modality I: Code 20020170100109BA.
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[15] Taylor GB, Paviour SD, Musaad S, Jones WO, Holland DJ. A clinic pathological review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. Pathology. 2003;35:109-19.
[2] Barberis C, Almuzara M, Join-Lambert O, Ramírez MS, Famiglietti A, Vay C. Comparison of the Bruker MALDI-TOF mass spectrometry system and conventional phenotypic methods for identification of Gram-positive rods. PLoS One. 2014;9:e106303, http://dx.doi.org/10.1371/journal.pone.0106303, eCollection 2014.
[3] Clinical and Laboratory Standards Institute. Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria. 2015, M45, 3rd ed. Wayne, PA.
[4] Collins MD, Falsen E, Akervall E, Sjöden B, Alvarez A. Corynebacterium kroppenstedtii sp. nov., a novel corynebacterium that does not contain mycolic acids. Int J Syst Bacteriol. 1998;48:1449-54.
[5] Dobinson HC, Anderson TP, Chambers ST, Doogue MP, Seaward L, Werno AM. Antimicrobial treatment options for granulomatous mastitis caused by Corynebacterium species. J Clin Microbiol. 2015;53:2895-9.
[6] Fernández-Natal I, Rodríguez-Lázaro D, Marrodán-Ciordia T, Sáez-Nieto JA, Valdezate S, Rodríguez-Pollán H, Tauch A Soriano F. Characterization and antimicrobial susceptibility of one antibiotic-sensitive and one multidrug-resistant Corynebacterium kroppenstedtii strain isolated from patients with granulomatous mastitis. New Microbes New Infect. 2016;14:93-7.
[7] Funke G, Bernard KA. Coryneform gram-positive rods. En: Versalovic J, Carroll KC, Funke G, Jorgensen JH, Landry ML, Warnock DW, editores. Manual of clinical microbiology. Washington DC: ASM Press; 2011. p. 413-42.
[8] Hagemann JB, Essig A, Herrmann M, Liebold A, Quader MA. Early prosthetic valve endocarditis caused by Corynebacterium kroppenstedtii. Int J Med Microbiol. 2015;305:957-9.
[9] Johnson MG, Leal S, Plongla R, Leone PA, Gilligan PH. Closing the brief case: recurrent granulomatous mastitis due to Corynebacterium kroppenstedtii. J Clin Microbiol. 2016;54:2212
[10] Kutsuna S, Mezaki K, Nagamatsu M, Kunimatsu J, Yamamoto K, Fujiya Y, et al. Two cases of granulomatous mastitis caused by Corynebacterium kroppenstedtii infection in nulliparous young women with hyperprolactinemia. Intern Med. 2015;54:1815-8.
[11] Paviour S, Musaad S, Roberts S, Taylor G, Taylor S, Shore K, et al. Corynebacterium species isolated from patients with mastitis. Clin Infect Dis. 2002;35:1434-40.
[12] Poojary I, Kurian AVAJ, Devapriya JDMAT. Corynebacterium species causing breast abscesses among patients attending a tertiary care hospital in Chennai, South India. Infect Dis (Lond). 2017;49:528-31.
[13] Rainer BM, Thompson KG, Antonescu C, Florea L, Mongodin EF, Bui J, et al. Characterization and analysis of the skin microbiota in rosacea: A case-control study. Am J Clin Dermatol. 2020;21:139-47.
[14] Tauch A, Fernández-Natal I, Soriano F. A microbiological and clinical review on Corynebacterium kroppenstedtii. Int J Infect Dis. 2016;48:33-9.
[15] Taylor GB, Paviour SD, Musaad S, Jones WO, Holland DJ. A clinic pathological review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. Pathology. 2003;35:109-19.
Copyright © 2025 Nahuel Sanchez Trump, Claudia Barberis, Rosana Cittadini, Ana María Ozuna Villca, María Florencia Veiga, Viviana Vilches, Carlos Vay, Marisa Almuzara
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