m6A修饰在创伤性脑损伤诱导神经损伤中的作用研究

Journal: Frontier Forum of Clinical Medicine DOI: 10.12238/ffcr.v3i2.14034

刘雨, 康倩倩, 刘欣宇, 马哲, 陈玉华

西安培华学院

Abstract

创伤性脑损伤(traumatic brain injury,TBI)被认为是重要的全球卫生优先事项,TBI可触发神经炎症、氧化应激、线粒体功能障碍等病理事件,并引发神经损伤和脑萎缩。该研究旨在进一步揭示TBI病生理的复杂机制,为TBI后神经损伤的治疗提供新的思路。RNA甲基化是转录后调控中最重要的修饰之一,而N6-甲基腺苷(N6-methyladenosine,m6A)修饰是真核生物中最丰富的mRNA转录后修饰。既往研究指出,m6A修饰通过表观遗传调控神经发育及神经系统疾病,可调控神经元损伤。该研究旨在阐述TBI诱导氧化应激和神经炎症的病理变化,探讨RNA m6A修饰在TBI后神经损伤中的特点,重点讨论将m6A作为治疗靶点来改善TBI引起氧化应激和神经炎症的潜在作用及机制,为TBI的治疗和预后提供新思路和药物作用新靶点。

Keywords

创伤性脑损伤;N6-甲基腺苷;神经元损伤

References

[1] Boulias K, Greer EL. Biological roles of adenine methylation in RNA[J]. Nat Rev Genet, 2023, 24(3): 143-160.
[2] Sendinc E, Shi Y. RNA m6A methylation across the transcriptome[J]. Mol Cell, 2023, 83(3): 428-441.
[3] Wang MK, Gao CC, Yang YG. Emerging roles of RNA methylation in development[J]. Acc Chem Res, 2023, 56(23): 3417-3427.
[4] Chen Y, Wang W, Zhang W, et al. Emerging roles of biological m6A proteins in regulating virus infection: A review[J]. Int J Biol Macromol, 2023, 253(Pt 3): 126934.
[5] Sikorski V, Selberg S, Lalowski M, et al. The structure and function of YTHDF epitranscriptomic m6A readers[J]. Trends Pharmacol Sci, 2023, 44(6): 335-353.
[6] Chen L, Gao Y, Xu S, et al. N6-methyladenosine reader YTHDF family in biological processes: Structures, roles, and mechanisms[J]. Front Immunol, 2023, 14: 1162607.
[7] Zou Z, Sepich-Poore C, Zhou X, et al. The mechanism underlying redundant functions of the YTHDF proteins[J]. Genome Biol, 2023, 24(1): 17.
[8] Ng SY, Lee AYW. Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets[J]. Front Cell Neurosci, 2019, 13: 528.

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