植物药用天然产物对T细胞调节作用的研究
Journal: Frontiers of Chinese Medicine Research DOI: 10.12238/fcmr.v6i4.11022
Abstract
植物药用天然产物(HMP)具有副作用小,用药安全范围广的显著优点,是现代新药研发以及发现新的模式化合物的重要源泉。其中很多的药用植物天然产物作用于T细胞,发挥良好的免疫调节作用,有必要对其进行系统地总结。
Keywords
植物药用天然产物；免疫调节；T细胞
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[4] IP F C F,NG Y P, OR T C T, et al. Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response [J]. PLoS One,2017,12(7):e0182069.
[5] LU Y, CHEN B, SONG J H, et al. Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells[J].Proc Natl Acad Sci U S A,2013,110(6): 2258-63.
[6] LI W, ZHANG Z, ZHANG K, et al. Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomye litis Through AMPK and PPAR-γ/ROR-γt Signaling[J].Mol Neu robiol, 2016, 53(8): 5356-66.
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[8] CUI G, QIN X,ZHANG Y,etal.Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice [J].J Biol Chem,2009,284(41):28420-9.
[9] YANG J,YANG X,LI M.Baicalin,a natural compound, promo tes regulatory T cell differentiation [J]. BMC Complement Altern Med,2012,12:64.
[10] YANG J, YANG X, CHU Y, et al. Identification of Baicalin as an immunoregulatory compound by controlling T(H)17 cell differentiation[J].PLoS One,2011,6(2):e17164.
[11] ASTRY B, VENKATESHA S H, LAURENCE A, et al. Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ[J].Clin Immunol,2015,157(2):228-38.
[12] NAMDARI H,IZAD M,REZAEI F,etal.Differential regulati on of CD4(+)T cell subsets by Silymarin in vitro and in ovalbu min immunized mice[J].Daru,2018,26(2):215-27.
[13] GHARAGOZLOO M,VELARDI E,BRUSCOLI S, et al. Silymarin suppress CD4+ T cell activation and proliferation: effects on NF-kappaB activity and IL-2 production[J].Pharmacol Res,2010, 61(5):405-9.
[14] CHENG C,ZHANG W,ZHANG C,etal.Hyperoside Ameliorates DSS-Induced Colitis through MKRN1-Mediated Regulation of PPARγ Signaling and Th17/Treg Balance [J]. J Agric Food Chem, 2021,69(50):15240-51.
[15] DIEJOMAOH M F. Recurrent spontaneous miscarriage is still a challenging diagnostic and therapeutic quagmire [J]. Med Princ Pract,2015,24 Suppl1(Suppl1):38-55.
[16] XUE W,GAO Y,LI Q,etal.Immunomodulatory activity-gui ded isolation and characterization of a novel polysaccharide from Atractylodis macrocephalae Koidz[J]. Int J Biol Macromol, 2020,161:514-24.
[17] ZHANG A,ZHENG Y,QUE Z,et al. Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO [J]. J Cancer Res Clin Oncol,2014,140(11):1883-90.
[18] HUANG W C, WU S J, YEH K W, et al. Gypenoside A from Gynostemma pentaphyllum Attenuates Airway Inflammation and Th2 Cell Activities in a Murine Asthma Model [J]. Int J Mol Sci,2022,23(14).
[19] JI N F, XIE Y C, ZHANG M S, et al. Ligustrazine corrects Th1/Th2 and Treg/Th17 imbalance in a mouse asthma model [J]. Int Immunopharmacol,2014,21(1):76-81.
[20] ZHANG B,ZENG M, ZHANG Q,etal.Ephedrae Herba polysac charides inhibit the inflammation of ovalbumin induced asth ma by regulating Th1/Th2 and Th17/Treg cell immune imbalance [J].Mol Immunol,2022,152:z4-26.
[21] ZHANG F,WANG Z, LI M, et al. Puerarin attenuates smoke inhalation injury by regulation of Th1/Th2 expression and inhibition of Th17 cells in rats[J].Int Immunopharmacol, 2015,28(1):546-53.
[22] YIN X,CHEN S,EISENBARTH S C.Dendritic Cell Regulation of T Helper Cells [J].Annu Rev Immunol,2021,39:759-90.
[23] BORDBAR N, KARIMI M H, AMIRGHOFRAN Z. The effect of glycyrrhizin on maturation and T cell stimulating activity of dendritic cells[J].Cell Immunol,2012,280(1):44-9.
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