HPLC法测定阿苯达唑有关物质
Journal: Frontiers of Chinese Medicine Research DOI: 10.12238/fcmr.v6i3.9254
Abstract
目的：探讨阿苯达唑有关物质的HPLC测定方法,方法：采用Welch AQ 250m*4.65μm色谱柱,梯度洗脱,流动相A：0.01mol.L-1乙酸铵(用甲酸调节pH至2.2),流动相B：甲醇,流速为1ml.min-1,波长为254nm与292nm。结果：阿苯达唑与各杂质有效分离,12个杂质在1~7μg.ml-1浓度范围内线性良好,回收率均在80%~120%之间。结论：该方法首次将阿苯达唑及12个已知杂质有效分离,方法简便,专属性强,可作为产品的质量检测方法。
Keywords
阿苯达唑；有关物质；HPLC；氧化杂质
Full Text
PDF - Viewed/Downloaded: 0 TimesReferences
[1] Ch.P(2010)Vol Ⅱ(中国药典2010年版.二部)[S].2010:393.
[2] BP 2011[S].2011:78-79.
[3] EP 7.0[S].2008:1335-1336.
[4] 郑爱华,黄金占,陈祖国.合成阿苯达唑的研究进展[J].浙江化工,2018(49):12.
[5] 李安良,许爱霞.阿苯达唑中杂质的检测[J].中国医药工业杂质,1991(22):8.
[6] 孙春艳,赵亚萍,郭江红.HPLC测定阿苯达唑有关物质[J].中国现代应用药学,2012(3):29.
[7] 刘志辉.HPLC测定阿苯达唑片的含量与有关物质[J].中国药师,2014(17):3.
[8] Haibo Zhanga,b,1,Jun Zhaoa,1,Bei Chena.Pharmacokinet ics and tissue distribution study of liposomal albendazole in naturally Echinococcus granulosus infected sheep by a validat ed UPLC-Q-TOF-MS method[J].Journal of Chromatography B,1141 (2020):122016.
[9] Yan Lin,a Yih Ching Ong,a Sarah Keller.Synthesis, charac terization and antiparasitic activity of organometallic deriv atives of the anthelmintic drug albendazole[J].Dalton Trans.,2020,(49)6616.
[2] BP 2011[S].2011:78-79.
[3] EP 7.0[S].2008:1335-1336.
[4] 郑爱华,黄金占,陈祖国.合成阿苯达唑的研究进展[J].浙江化工,2018(49):12.
[5] 李安良,许爱霞.阿苯达唑中杂质的检测[J].中国医药工业杂质,1991(22):8.
[6] 孙春艳,赵亚萍,郭江红.HPLC测定阿苯达唑有关物质[J].中国现代应用药学,2012(3):29.
[7] 刘志辉.HPLC测定阿苯达唑片的含量与有关物质[J].中国药师,2014(17):3.
[8] Haibo Zhanga,b,1,Jun Zhaoa,1,Bei Chena.Pharmacokinet ics and tissue distribution study of liposomal albendazole in naturally Echinococcus granulosus infected sheep by a validat ed UPLC-Q-TOF-MS method[J].Journal of Chromatography B,1141 (2020):122016.
[9] Yan Lin,a Yih Ching Ong,a Sarah Keller.Synthesis, charac terization and antiparasitic activity of organometallic deriv atives of the anthelmintic drug albendazole[J].Dalton Trans.,2020,(49)6616.
Copyright © 2024 孙海玲, 陶怡, 谭金玲, 姜石畅, 鲍实
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License