干细胞联合中药方剂治疗心肌梗死的研究进展
Journal: Frontiers of Chinese Medicine Research DOI: 10.12238/fcmr.v4i2.5469
Abstract
心肌梗死(myocardial infarction,MI)是全世界范围内死亡率最高的疾病,也是致死率和致残率的首要因素之一。传统的治疗手段仅能改善症状而不能替换修复损伤的心肌细胞,这就迫切需要一种新型的治疗手段来修复改善心肌梗死。干细胞技术的发展以及干细胞特有的增殖分化能力使其成为再生医学极具潜力的工具。中药中的经典方剂“补阳还五汤”能够改善心肌梗死微环境,促进微小血管形成,同时具有抗炎,调节免疫等作用。综上,干细胞结合中药方剂共同用于心梗治疗应该会有较好的疗效。
Keywords
心肌梗塞；干细胞；中药方剂；补阳还五汤
Funding
(1)浙江省中医药科技计划青年人才基金项目,2019ZQ034；(2)浙江省自然科学基金青年基金项目,LQ19H180009。
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[1] Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR,Deo R, et al. Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation. 2017;135:e146-e603.
[2] Bauters C, Dubois E, Porouchani S, Saloux E, Fertin M, de Groote P, et al. Long-term prognostic impact of left ventricular remodeling after a first myocardial infarction in modern clinical practice. PLoS One. 2017;12:e0188884.
[3] Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292: 154-6.
[4] Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A. 1981; 78:7634-8.
[5] Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145-7.
[6] Hong H, Yang Y, Zhang Y, Cai W. Non-invasive imaging of human embryonic stem cells. Curr Pharm Biotechnol. 2010;11: 685-92.
[7] Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-76.
[8] Zhao M, Nakada Y, Wei Y, Bian W, Chu Y, Borovjagin AV, et al. Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction. Circulation. 2021;144:210-28.
[9] Guo R, Morimatsu M, Feng T, Lan F, Chang D, Wan F, et al. Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction. Stem Cell Res Ther. 2020;11:19.
[10] Gao L, Gregorich ZR, Zhu W, Mattapally S, Oduk Y, Lou X, et al. Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine. Circulation. 2018;137:1712-30.
[11] Friedenstein AJ, Chailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV. Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantat ion.1974;17:331-40.
[12] Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9:641-50.
[13] Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stemcells.Science.1999;284:143-7.
[14] Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK, et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant. 2005;11:389-98.
[15] Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A. 2001;98:10344-9.
[16] Laflamme MA, Zbinden S, Epstein SE, Murry CE. Cellbased therapy for myocardial ischemia and infarction: path ophysiological mechanisms. Annu Rev Pathol.2007;2:307-39.
[17] Shen JF, Sugawara A, Yamashita J, Ogura H, Sato S. Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues. Int J Oral Sci. 2011;3:117-24.
[18] Li L, Wang Y, Guo R, Li S, Ni J, Gao S, et al. Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusi on injury. Journal of controlled release : official journal of the Controlled Release Society. 2020;317:259-72.
[19] 李卿,周春刚.补阳还五汤防治心肌缺血/再灌注损伤的研究进展[J].医学综述,2015,21(11):2032-2033．
[20] 李鑫辉,黄淼鑫,杜建芳,等.丹参通络解毒汤联合骨髓干细胞移植对急性心肌梗死大鼠心肌纤维化的影响及其机制[J].北京中医药大学报,2019,42(8):655-661．
[21] 宋忠阳,王功臣,张志明,等.补阳还五汤联合 BMSCs对心肌缺血再灌注损伤模型大鼠心肌的防护作用[J].北京中医药大学学报,2020,43(2):115-124．
[2] Bauters C, Dubois E, Porouchani S, Saloux E, Fertin M, de Groote P, et al. Long-term prognostic impact of left ventricular remodeling after a first myocardial infarction in modern clinical practice. PLoS One. 2017;12:e0188884.
[3] Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292: 154-6.
[4] Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A. 1981; 78:7634-8.
[5] Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145-7.
[6] Hong H, Yang Y, Zhang Y, Cai W. Non-invasive imaging of human embryonic stem cells. Curr Pharm Biotechnol. 2010;11: 685-92.
[7] Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-76.
[8] Zhao M, Nakada Y, Wei Y, Bian W, Chu Y, Borovjagin AV, et al. Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction. Circulation. 2021;144:210-28.
[9] Guo R, Morimatsu M, Feng T, Lan F, Chang D, Wan F, et al. Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction. Stem Cell Res Ther. 2020;11:19.
[10] Gao L, Gregorich ZR, Zhu W, Mattapally S, Oduk Y, Lou X, et al. Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine. Circulation. 2018;137:1712-30.
[11] Friedenstein AJ, Chailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV. Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantat ion.1974;17:331-40.
[12] Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9:641-50.
[13] Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stemcells.Science.1999;284:143-7.
[14] Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK, et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant. 2005;11:389-98.
[15] Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A. 2001;98:10344-9.
[16] Laflamme MA, Zbinden S, Epstein SE, Murry CE. Cellbased therapy for myocardial ischemia and infarction: path ophysiological mechanisms. Annu Rev Pathol.2007;2:307-39.
[17] Shen JF, Sugawara A, Yamashita J, Ogura H, Sato S. Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues. Int J Oral Sci. 2011;3:117-24.
[18] Li L, Wang Y, Guo R, Li S, Ni J, Gao S, et al. Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusi on injury. Journal of controlled release : official journal of the Controlled Release Society. 2020;317:259-72.
[19] 李卿,周春刚.补阳还五汤防治心肌缺血/再灌注损伤的研究进展[J].医学综述,2015,21(11):2032-2033．
[20] 李鑫辉,黄淼鑫,杜建芳,等.丹参通络解毒汤联合骨髓干细胞移植对急性心肌梗死大鼠心肌纤维化的影响及其机制[J].北京中医药大学报,2019,42(8):655-661．
[21] 宋忠阳,王功臣,张志明,等.补阳还五汤联合 BMSCs对心肌缺血再灌注损伤模型大鼠心肌的防护作用[J].北京中医药大学学报,2020,43(2):115-124．
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