银屑病与前列腺癌的因果关系：一项双向孟德尔随机化分析
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i6.17061
Abstract
目的：探讨银屑病（Psoriasis, PS）与前列腺癌（Prostate cancer, PCa）之间的因果关系。本研究通过双向孟德尔随机化（Mendelian randomization, MR）分析评估两者的因果方向。方法：本研究使用两项大规模欧洲人群全基因组关联研究（Genome-Wide Association Studies, GWAS）的汇总数据：PS（5,314例病例和457,619例对照）与PCa（79,148例病例和61,106例对照）。主要分析方法为反方差加权（Inverse-variance weighted, IVW），并采用MR-Egger、加权中位数（Weighted median）、加权模型（Weighted mode）和简单模型（Simple mode）进行敏感性分析。横向多效性通过MR-PRESSO全局检验和MR-Egger回归评估，异质性采用Cochran’s Q统计量检验，并通过逐一剔除（Leave-one-out）分析验证结果稳定性。结果：正向MR分析显示，PS与PCa风险降低之间存在统计学显著的遗传学关联（OR=0.205，95%CI: 0.067–0.628，P=0.005）。然而，反向MR分析未发现PCa对PS存在因果关系（OR=1.000，95%CI: 0.999–1.001，P=0.821）。结论：本研究未发现欧洲人群中PS与PCa之间存在双向因果关系。结果提示，PS可能与PCa发病风险的遗传性降低相关，而PCa似乎对PS风险没有遗传因果效应。
Keywords
孟德尔随机化；银屑病；前列腺癌；因果分析；全基因组关联研究（GWAS）
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